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- W2381639478 abstract "Objective:To investigate the difference effects in intrapulmonary shunt and pulmonary dynamic compliance between sufentanil-propofol by target-controlled infusion and isoflurane during one-lung ventilation.Methods:Twenty ASA ⅠorⅡ patients undergoing radical esophagus cancer resection via left thoracotomy were randomly divided into 2 equal groups(n=10 each):the sufentanil and propofol group(SUF) and the isoflurance group(ISO).In SUF group anesthesia was maintained with TCI of sufentanil and propofol(targeting effect-site concentration was set at 0.5 ng/ml and 3(g/ml);In ISO group,anesthesia was maintained with isoflurance.Arterial and pulmonary blood gases were analyzed 30 min after TLV was started(T0),and 30,60,90 min after OLV was started(T1,T2,T3).The intrapulmonary shunt fraction(Qs/Qt) and pulmonary dynamic compliance(Cdyn) was calculated at T0-T3.Results:The PaCO2 and pH were within normal range in both groups.Qs/Qt was significantly increased while PaO2 and Cdyn was significantly decreased during operation(from T1 to T3)as compared to baseline values(T0),but Qs/Qt decreasing while PaO2 was increasing from T2-T3 in both groups.Qs/Qt was significantly lower in SUF group than in ISO group at each interval(T1-T3),Cdyn was significantly high in SUF group than ISO group at each interval(T1-T3)but there no significant difference in PaO2 at T2-T3 between the two groups.Conclusion:Compared with isoflurane anesthesia,there is less intrapulmonary shunt and high pulmonary dynamic compliance during OLV under general anesthesia with sufentanil-propofol,but the difference is not significant enough to affect PaO2." @default.
- W2381639478 created "2016-06-24" @default.
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- W2381639478 date "2011-01-01" @default.
- W2381639478 modified "2023-09-28" @default.
- W2381639478 title "Effects of general anesthesia by TCI sufentanil and propofol on intrapulmonary shunt during one-lung ventilation" @default.
- W2381639478 hasPublicationYear "2011" @default.
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