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- W2381639863 abstract "Objective To investigate the effect of C23 over-expression on inhibition of proliferation and apoptosis induced by cisplatin in human osteosarcoma SaOS-2 cells. Methods C23 recombinant plasmid was constructed using gene engineering and was tested by sequence analysis.SaOS-2 cells were divided into four groups randomly: control group,CDP group,V(vector) + CDP group and P(plasmid) + CDP group.Cell growth suppression of each group was analyzed by MTT assay.RT-PCR and immunoblotting were used to detect the expression of C23,Bcl-2 and Bax mRNA and protein in each group.Morphologic character of apoptosis was evaluated by DAPI staining.The percentage of apoptotic cell was analyzed by flowcytometer assay. Results C23 recombinant plasmid was constructed successfully.C23 over-expression could block significantly the inhibition of proliferation induced by cisplatin,there showed statistically significant difference between P+CDP group and CDP group(P0.01).The expression of C23 and Bcl-2 mRNA and protein were stronger and that of Bax mRNA and protein were weaker in P+CDP group than in CDP group(P0.01).Over expression of C23 could significantly inhibit cisplatin-mediated apoptosis in SaOS-2 cells with a lower percentage of apoptotic cells compared with CDP group. Conclusions Over-expression of C23 could increase resistance of SaOS-2 cells to cisplatin." @default.
- W2381639863 created "2016-06-24" @default.
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- W2381639863 date "2011-01-01" @default.
- W2381639863 modified "2023-09-23" @default.
- W2381639863 title "Study on the Effect of C23 Over-expression on Inhibition of Proliferation and Apoptosis Induced by Cisplatin in Human Osteosarcoma SaOS-2 Cells" @default.
- W2381639863 hasPublicationYear "2011" @default.
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