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- W2381640331 abstract "Objective To explore the relationship of the expression of COX-2 and E-cadherin,MMP-2,and the mechanism of COX-2 involvement in the tumor cell invasion and migration.Methods Celecoxib had been used to intervene in the gastric carcinoma cell line SGC7901,the real-time quantitative PCR was used to detect the levels of COX-2,E-cadherin and MMP-2 mRNA.The combination immunofluorescence and confocal laser scanning microscopy was used to analyze the expression of E-cadherin protein.Transwell was used to detect the effect of celecoxib on the invasion and migration of human gastric carcinoma cells.Results Celecoxib significantly inhibited the expression of COX-2 mRNA,with a corresponding E-cadherin mRNA expression gradually increased and MMP-2 mRNA expression gradually decreased.Application of celecoxib(30 μmol/L) treatment in human gastric cancer cell SGC-7901,the confocal laser fluorescence microscope scanning detected that the expression of E-cadherin protein at 24,36,48 hours significantly increased.The number of cells in celecoxib treated group through the Transwell chamber was less than the number of cells in the control group.Conclusion Selective COX-2 inhibitor celecoxib may up-regulate the expression of E-cadherin,and down-regulate the expression of MMP-2,which can inhibite the invasion and migration of human gastric carcinoma by suppressing the expression of COX-2 in vitro." @default.
- W2381640331 created "2016-06-24" @default.
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- W2381640331 date "2012-01-01" @default.
- W2381640331 modified "2023-09-28" @default.
- W2381640331 title "The effect of celecoxib on the expression of E-cadherin and MMP-2 in human gastric carcinoma cell line SGC7901 in vitro" @default.
- W2381640331 hasPublicationYear "2012" @default.
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