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- W2381642262 abstract "Objective: The aim of the present study was to research the effects of Th17/Treg imbalance in patients with chronic HBV infection in varying degrees.Methods: The study involved 65 patients treated at the second Affiliated Hospital of Chongqing Medical University,including 7 with asymptomatic HBV carriers(AsC),38 with chronic hepatitis B in low or moderate grade(CHB-LM),20 with Chronic Severe Hepatitis B(CSHB),and 10 healthy subjects as controls(HC).We examined the frequency of peripheral blood Th17 cells and Treg cells by flow cytometry,related-cytokines levels measured by Enzyme-linked immunosorbent assay(ELISA).Results: The frequency of Th17 cells is obviously increase in CSHB group,and the frequency of Treg cells of AsC group is highest,the propotion of Th17 cells and Treg cells is negatively correlated.The related cytokines concentration(IL-1β,IL-6 an IL-21) are all increase in CSHB group,but there were no significant difference in plasma TGF-βamong groups.Conclusions: Th17 and Treg cells have immune imbalance in different disease stages of chronic hepatitis B.In the immune tolerance phase.Treg cells have the major role,and in inflammatory phase of activity,Th17 cells play the important role." @default.
- W2381642262 created "2016-06-24" @default.
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- W2381642262 date "2012-01-01" @default.
- W2381642262 modified "2023-09-24" @default.
- W2381642262 title "The Role of Immunoregulation by Th17 and Treg Cells in the Pathogenesis of Chronic HBV Infection" @default.
- W2381642262 hasPublicationYear "2012" @default.
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