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- W2381651285 abstract "OBJECTIVE:To explore the in vitro and in vivo course of BCNU released from BCNU-PLA-MS and its location in rat brain tissue.METHODS:The concentrations of BCNU in PBS and brain tissue were determined by high performance liquid chromatography and 3H-labeled BCNU was used to determine the location in normal brain tissue and serum.RESULTS:The BCNU could be sustainedly released from BCNU-PLA-MS over 2 weeks both in PBS and in brain tissue.In PBS,the released rate of BCNU was over 15% in 1d,nearly 50% in 3d and over 90% in 15d.In brain tissue,the released rate was 8% in 4h,16% in 1d,60% in 3d,respectively,and BCNU could be sustainedly released over 15 days.The concentrations of BCNU in ipsilateral was 6 to 70 times higher than those in contralateral.CONCLUSIONS:BCNU-PLA-MS are safe and biocompatible." @default.
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- W2381651285 date "2007-01-01" @default.
- W2381651285 modified "2023-09-23" @default.
- W2381651285 title "In Vitro and In Vivo Release and Distribution of BCNU-PLA Microspheres" @default.
- W2381651285 hasPublicationYear "2007" @default.
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