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- W2381652214 abstract "Objective: To compare the different expression of amelogenin(AMELX), ameloblastin(AMBN) and enamelin(ENAM) in tooth germs, thus to clarify the functions of these proteins in the development of tooth. Methods: The mice whose tooth germs were in bell stage, late bell stage and enamel mature stage were selected. The expression of these three proteins in the sagital sections of these mice was detected by immunohistochemistry, and EnVision two steps method was applied. The antibodies were presented from Dr. Simmer. Results: Immunohistochemistry showed that the temporal and spatial expression patterns of AMELX, AMBN and ENAM in ameloblasts and enamel matrix were different. With the mineralization of enamel matrix, expression of AMELX decreased, but it weakly expressed in adjacent bone. At the same time, expression of AMBN and ENAM were more stable. Conclusion: AMELX, AMBN and ENAM are the major matrix proteins of enamel, and play different roles during different developing stages of tooth germs. AMELX may facilitate the growth of crystals in the early mineral stage, and act in the repairing of bone. AMBN may promote the mineralization of enamel matrix, and also keep the shape and size of crystals. ENAM may act in remineralization and promoting the growth of crystals." @default.
- W2381652214 created "2016-06-24" @default.
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- W2381652214 date "2006-01-01" @default.
- W2381652214 modified "2023-09-23" @default.
- W2381652214 title "Expression of Amelogenin, Ameloblastin and Enamelin in Developing Tooth Germs of Mouse" @default.
- W2381652214 hasPublicationYear "2006" @default.
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