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- W2381660358 abstract "OBJECTIVE:To establish a DDP-resistant cell line from human nasopharyngeal carcinoma cell line HNE1 and to investigate the relationship between drug-resistance and apoptosis.METHODS:A cisplatin-resistant human nasopharyngeal carcinoma cell line,HNE1/DDP,was induced by continuously exposing and gradually increasing dose of cisplatin.The resistant index was estimated by MTT assay.Cell growth curve,doubling time and cycle phase distribution were measured.The apoptosis index was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).Apoptosis-related proteins of p53,Bcl-2 and Bax expression were examined by immuocytochemistry.RESULTS:The cisplatin-resistant cell line HNE1/DDP was established with the resistant index of 5.57.The proliferation of HNE1/DDP got slow;doubling time prolonged(41.85 h vs 37.44 h,P=0.035);and the cell number of S-phase and G2/M-phase decreased while the G0/G1 phase increased compared with parental cells.The apoptosis index(3.80±0.26 vs 21.43±0.11,χ2=13.211,P=0.001);and the expression of Bax(1.52±0.16 vs 16.05±5.11,χ2=11.966,P=0.001) decreased.CONCLUSIONS:The stable cisplatin-resistant cell line HNE1/DDP has been established.The mechanism of resistance is partly due to the decrease of apoptosis." @default.
- W2381660358 created "2016-06-24" @default.
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- W2381660358 date "2008-01-01" @default.
- W2381660358 modified "2023-09-23" @default.
- W2381660358 title "Establishment of cisplatin-resistant cell line HNE1/DDP and the relationship betweendrug-resistance and apoptosis" @default.
- W2381660358 hasPublicationYear "2008" @default.
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