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- W2381660754 abstract "Objective To investigate the interventional effect of puerarin(Pur)preconditioning on focal cerebral ischemia-reperfusion(IR)injury in rats and to explore the possible therapeutic time window.Methods Fourty male Sprague-Dawley rats were randomly divided into IR,Pur preconditioning(PC)-6h,PC-12h,PC-24hand PC-48hgroups(n=8).100mg·kg-1 Pur was given at 6,12,24or 48hbefore cerebral ischemia in the rats in last four groups,0.9%saline 1ml·kg-1 was injected ip at the end of 90min ischemia in the rats in IR group.A focal cerebral ischemia reperfusion model was induced by the middle cerebral artery intraluminal suture method.All animals were subjected to the left middle cerebral artery occlusion for 90min,followed by reperfusion for 24h. The neurological deficit score was measured at 24hafter IR.The brain infarct volume percentage(BIVP)was then assessed after 2%TTC staining following the last neurological outcome evaluation.Results Compared with IR group,the neurologic deficit scores in PC-6h,PC-12hand PC-24hgroups were statistically improved(P0.01), but not in PC-48hgroup(P0.05).The BIVP in PC-6h,PC-12hand PC-24hgroup were significantly decreased compared with IR group(P0.01).No statistically significant difference in BIVP was found between IR group and PC-48hgroup(P0.05).There were no statistically significant differences in neurologic deficit score and BIVP between PC-6h,PC-12hand PC-24hgroups(P0.05).Conclusion Pur precondioning can protect rat brain against IR injury.The therapeutic time window of Pur neuroprotection may be over 24h." @default.
- W2381660754 created "2016-06-24" @default.
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- W2381660754 date "2014-01-01" @default.
- W2381660754 modified "2023-09-24" @default.
- W2381660754 title "Protective effects of puerarin preconditioning on focal cerebral ischemia-reperfusion injury in rats and its therapeutic time window" @default.
- W2381660754 hasPublicationYear "2014" @default.
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