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- W2381696468 abstract "Objective To improve the permeation of nasal mucosa by preparing the cholic acid-hydroxypropyl-β-cyclodextrin(HP-β-CD) and characterize the inclusion complex.Methods The inclusion complex was characterized by using phase solubility,scanning electron microscope(SEM),Fourier transform-infrared(FT-IR),differential scanning calorimetry(DSC),and superconducting NMR;In an effort to investigate the effect of HPβ-CD on cholic acid,the studies of in vitro permeation of nasal mucosa was performed.Results Phase solubility curve was AL type,K=564.30 L/mol,and the characterization de-monstrates the formation of inclusion complex;The permeability coefficients and steady state fluxes through ovine and porcine nasal mucosa were enhanced by the formation of inclusion complex with HP-β-CD about 1.46 and 1.44 times of the uncomplexed cholic acid,respectively.Conclusion The inclusion complex is formed and it could increase the permeability of nasal mucosa by preparing the cholic acid-HP-β-CD." @default.
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- W2381696468 date "1994-01-01" @default.
- W2381696468 modified "2023-09-27" @default.
- W2381696468 title "Characterization and in vitro permeation of nasal mucosa evaluation of inclusion complex of cholic acid-hydroxypropyl-β-cyclodextrin" @default.
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