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- W2381725657 abstract "Background and purpose:Chk1/2 (checkpoint kinase 1/2) and Plk1(polo-like kinase 1)played the major role in the regulation of cell cycle when DNA was damaged. The aim of this study was to explore the association of these kinases with clinical pathology parameters of benign cervical lesions, malignant neoplasms and investigate the correlations between each other. Methods:Immunohistochemistry was applied to detect the expressions of Chk1, Chk2 and Plk1 in 43 cases of cervical carcinoma and 20 cases of chronic cervicitis.Results:The positive percenuages of Chk1, Chk2 and Plk1 were 76.7%,60.5% and 32.6% respectively in cervical carcinoma, and compared with 30.0%,35.0% and 0, respectively in chronic cervicitis; there were statistically significant higher expressions of Chk1 and Plk1 proteins in cervical carcinoma than that in chronic cervicitis (P0.01) except to Chk2, The expressions of Chk1, Chk2 and Plk1 were not associated with the age, pathology and clinical stage of cervical carcinoma patients (P0.05), while Chk1 and Plk1 expressions associated with differentiation of cervical carcinoma (P0.05). In 43 cervical carcinoma cases, Chk1 expression was positively correlated with Chk2 expression(r=0.492,P=0.001).Conclusions:Chk1 and Plk1 might be the ideal targets for cervical carcinoma therapy." @default.
- W2381725657 created "2016-06-24" @default.
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- W2381725657 date "2007-01-01" @default.
- W2381725657 modified "2023-09-24" @default.
- W2381725657 title "The expression of Chk1/2 and Plk1 protein in cervical carcinoma and chronic cervicitis and its significance" @default.
- W2381725657 hasPublicationYear "2007" @default.
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