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- W2381738897 abstract "Objective To detect SNPs in the IL-1RN and TNF-α gene in ankylosing spondylities(AS) .Method 54 patients diagnosed with AS in accordance with 1984' diagnostic criteria and 42 health control subjects were included in this study.The gene polymorphism of IL-1RN31017 C/G、 IL-1RN30735 T/C and TNF-α-857 T/C was analyzed.Result In the subjects with AS,the frequency of G allele in IL-1RN31017 C/G and C allele in 30735 T/C was higher than the healthy control subjects(60.42% vs 36.36%,32 % vs 17.19% respectively,P 0.01) .The frequency of GG allele in IL-1RN31017(43.75% vs 12.12% in control) and the frequency of CT allele in IL-1RN30375(64% vs 39.39% in control) was significantly higher than the control subjects(P 0.01) .The frequency of the T at SNP position-857 and the phenotype-857CT frequency was also significantly increased in AS(25% vs 9.52% and 42.59% vs 19.05% respectively,P 0.01) .To compare the genotypic combination with the non-genotypic combination,the frequency of the 31017CG/857CC genotypic combination in healthy controls was higher than AS(P 0.01) .The frequency of the 31017GG/30735CT/857CT genotypic combination in AS was higher than the healthy control subjects(P 0.05) .Conclusion There is a significant correlation between AS and the SNPs of IL-1RN 31017C/G and 30735 T/C.The occurrence of these genotypes is apparent in the Chinese Han population.Individuals with the 31017GG/30735CT/857CT genotypic combination are at high risk with AS." @default.
- W2381738897 created "2016-06-24" @default.
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- W2381738897 date "2007-01-01" @default.
- W2381738897 modified "2023-09-28" @default.
- W2381738897 title "Single Nucleotide Polymorphism of IL-1RN and TNF-α in Ankylosing Spondylitis" @default.
- W2381738897 hasPublicationYear "2007" @default.
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