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- W2381742012 abstract "AIM To investigate the influence of β 3 adrenoreceptor (β 3 AR) and the effect of β 3 AR agonist on the failing hearts. METHODS Rats were randomly divided into control group, isoprenaline(Iso) group and Iso+BRL group. Iso group and Iso+BRL group received two sc injections of Iso (340 mg·kg -1 ) with a 24 h interval to induce heart failure. After 8 weeks, Iso+BRL group was given BRL 37344 0.4 nmol·kg -1 ·min -1 via tail vein for 10 min, twice a week for 2 or 6 weeks. Mortality, hemodynamics, ratio of left ventricle weight and body weigh (LVW/BW) and levels of β 1 , β 2 and β 3 AR mRNA were measured at the tenth and the fourteenth week after injection of Iso. RESULTS There was no significant difference in the mortality among the three groups(P0.05). Left ventricular end systolic pressure (LVESP),±dp/dt max decreased, and left ventricular end diastolic pressure (LVEDP), LVW/BW increased dramatically in Iso group. When compared with Iso hearts, Iso+BRL group had more deteriorated cardiac functions and higher LVW/BW. The level of β 1 AR mRNA was low and the level of β 3 AR mRNA was high in Iso group. When compared with Iso hearts, Iso+BRL group had lower level of β 1 AR mRNA and higher level of β 3 AR mRNA. The level of β 2 AR mRNA had no significant difference among three groups. CONCLUSION In failing hearts, reduction in β 1 AR mRNA and increase in β 3 AR mRNA might contribute to cardiac dysfunctions; the level of β 3 AR mRNA is higher than that in control heart; β 3 AR agonist aggravates cardiac dysfunctions." @default.
- W2381742012 created "2016-06-24" @default.
- W2381742012 creator A5066670150 @default.
- W2381742012 date "2004-01-01" @default.
- W2381742012 modified "2023-09-25" @default.
- W2381742012 title "Effects of BRL-37344 on expression of β-adrenoreceptors mRNA of rats with heart failure" @default.
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