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- W2381742838 abstract "Objective:To study the relationship between genetic polymorphisms of phaseⅠ(CYP2E1、CYP2D6 and CYP3A4) and phase Ⅱ(GSTM1、GSTT1、GSTP1 and UGT1F)drug metabolizing enzymes(DEMs)and susceptibility to hepatocellular carcinoma(HCC).Methods:The polymorphisms of DMEs above in 84 cases with HCC and 144 healthy controls were detected by PCR.Results:Through univarate and multivariate statistical analysis,GSTM1 nu11 genotype,GSTT1 null genotype,genotype c1/c1of CYP2E1,and genotype G/G at position 754 of UGT1F were susceptible genotype to HCC.And the results of combined analysis showed that both the numbers of susceptible genotype and the risks to HCC were increased.Conclusion:CYP2E1,GSTM1,GSTT1,and UGT1F genes were useful markers for screening the population at high risk of HCC." @default.
- W2381742838 created "2016-06-24" @default.
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- W2381742838 date "2003-01-01" @default.
- W2381742838 modified "2023-09-25" @default.
- W2381742838 title "Study of Relationship Between Genetic Polymorphisms of Drug Metabolizing enzymes and Susceptibility to Hepatocellular Carcinoma" @default.
- W2381742838 hasPublicationYear "2003" @default.
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