Matches in SemOpenAlex for { <https://semopenalex.org/work/W2381772510> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2381772510 abstract "Objective To investigate the effects and mechanism of pentoxifylline on nonalcoholic steatohepatitis. Methods Thirty SD rats were divided into 3 groups randomly:model group (n=10),treatment group(n=10),and normal control group(n=10). The rats of model group and treatment group were given fat-rich feed,and those of normal control group were given normal feed. Furthermore,the rats of treatment group were given pentoxifylline after 12 weeks of fat-rich diet feeding. At 16 weeks,the rats of treatment group,normal control group and model group were sacrificed. Livers were reserved to measure the procollagen Ⅰ,procollagen Ⅲ,TGF-β1 and TNF-α mRNA expression by real-time PCR. Results The model group's procollagenⅠmRNA expression level was higher than that of the normal control group(P0.05),that of the treatment group was lower than that of the model group(P0.05). Model group's procollagen Ⅲ mRNA expression level was higher than that of the normal control group(P0.05),that of the treatment group was lower than that of the model group,but the differences were no statistically significant. The model group's TGF-β1 mRNA expression level was higher than that of normal control group(P0.05),that of treatment group was lower than that of model group(P0.05). Model group's TNF-α mRNA expression level was higher than that of normal control group(P0.05),and that of treatment group was lower than that of model group(P0.05). Conclusion Pentoxifylline can decrease the collagen Ⅰand collagen Ⅲ mRNA expression of nonalcoholic steatohepatitis,inhibit TGF-β1 and TNF-α expression. Pentoxifylline may have certain anti-fibrotic effects." @default.
- W2381772510 created "2016-06-24" @default.
- W2381772510 creator A5008566878 @default.
- W2381772510 date "2009-01-01" @default.
- W2381772510 modified "2023-09-28" @default.
- W2381772510 title "A Trial of Pentoxifylline in Rat Nonalcoholic Steatohepatitis" @default.
- W2381772510 hasPublicationYear "2009" @default.
- W2381772510 type Work @default.
- W2381772510 sameAs 2381772510 @default.
- W2381772510 citedByCount "0" @default.
- W2381772510 crossrefType "journal-article" @default.
- W2381772510 hasAuthorship W2381772510A5008566878 @default.
- W2381772510 hasConcept C104317684 @default.
- W2381772510 hasConcept C105580179 @default.
- W2381772510 hasConcept C126322002 @default.
- W2381772510 hasConcept C134018914 @default.
- W2381772510 hasConcept C2776954865 @default.
- W2381772510 hasConcept C2778772119 @default.
- W2381772510 hasConcept C2779134260 @default.
- W2381772510 hasConcept C2780404050 @default.
- W2381772510 hasConcept C2992013202 @default.
- W2381772510 hasConcept C3018708256 @default.
- W2381772510 hasConcept C3019114686 @default.
- W2381772510 hasConcept C55493867 @default.
- W2381772510 hasConcept C64348721 @default.
- W2381772510 hasConcept C71924100 @default.
- W2381772510 hasConcept C86803240 @default.
- W2381772510 hasConcept C90924648 @default.
- W2381772510 hasConceptScore W2381772510C104317684 @default.
- W2381772510 hasConceptScore W2381772510C105580179 @default.
- W2381772510 hasConceptScore W2381772510C126322002 @default.
- W2381772510 hasConceptScore W2381772510C134018914 @default.
- W2381772510 hasConceptScore W2381772510C2776954865 @default.
- W2381772510 hasConceptScore W2381772510C2778772119 @default.
- W2381772510 hasConceptScore W2381772510C2779134260 @default.
- W2381772510 hasConceptScore W2381772510C2780404050 @default.
- W2381772510 hasConceptScore W2381772510C2992013202 @default.
- W2381772510 hasConceptScore W2381772510C3018708256 @default.
- W2381772510 hasConceptScore W2381772510C3019114686 @default.
- W2381772510 hasConceptScore W2381772510C55493867 @default.
- W2381772510 hasConceptScore W2381772510C64348721 @default.
- W2381772510 hasConceptScore W2381772510C71924100 @default.
- W2381772510 hasConceptScore W2381772510C86803240 @default.
- W2381772510 hasConceptScore W2381772510C90924648 @default.
- W2381772510 hasLocation W23817725101 @default.
- W2381772510 hasOpenAccess W2381772510 @default.
- W2381772510 hasPrimaryLocation W23817725101 @default.
- W2381772510 hasRelatedWork W2272865606 @default.
- W2381772510 hasRelatedWork W2349029029 @default.
- W2381772510 hasRelatedWork W2349244336 @default.
- W2381772510 hasRelatedWork W2349856221 @default.
- W2381772510 hasRelatedWork W2356316929 @default.
- W2381772510 hasRelatedWork W2366374861 @default.
- W2381772510 hasRelatedWork W2367819530 @default.
- W2381772510 hasRelatedWork W2371452568 @default.
- W2381772510 hasRelatedWork W2373218609 @default.
- W2381772510 hasRelatedWork W2373652955 @default.
- W2381772510 hasRelatedWork W2379355068 @default.
- W2381772510 hasRelatedWork W2379801477 @default.
- W2381772510 hasRelatedWork W2381254624 @default.
- W2381772510 hasRelatedWork W2383312406 @default.
- W2381772510 hasRelatedWork W2384462769 @default.
- W2381772510 hasRelatedWork W2388079283 @default.
- W2381772510 hasRelatedWork W2388885917 @default.
- W2381772510 hasRelatedWork W2392196574 @default.
- W2381772510 hasRelatedWork W3028634007 @default.
- W2381772510 hasRelatedWork W608190394 @default.
- W2381772510 isParatext "false" @default.
- W2381772510 isRetracted "false" @default.
- W2381772510 magId "2381772510" @default.
- W2381772510 workType "article" @default.