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- W2381773736 abstract "Focal cerebral ischemia model was established by using nylon line occlusion of the middle cerebral arteryof rats. Hydroxysafflor yellow A(1, 2 and 4mg/kg), nimodipine(2mg/kg) and saline were administrated by caudal veininjection after ischemia for 2h. The focal cerebral ischemia-reperfusion model was obtained by taking out the nylon line after4h. The neurological deficit, the ratio of cerebral infarction area to total brain area and pathological histological changes ofcerebral infarction were investigated after ischemia for 24h. The results showed that compared with the saline group, themiddle and high dosage groups of hydroxysafflor yellow A could significantly improve the neurological deficit and decreasethe ratio of cerebral infarction, low dosage group could only improve the neurological deficit. The therapeutic effects of thethree groups were better than nimodipine group. The results of pathological histological examination showed thathydroxysafflor yellow A could modify the cellular necrosis status." @default.
- W2381773736 created "2016-06-24" @default.
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- W2381773736 date "2006-01-01" @default.
- W2381773736 modified "2023-09-27" @default.
- W2381773736 title "Neuroprotective Effects of Hydroxysafflor Yellow A on Focal Cerebral Ischemia-Reperfusion Injury in Rats" @default.
- W2381773736 hasPublicationYear "2006" @default.
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