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- W2381781189 abstract "Objective:To observe the expression of bcl-2,p53,cathepsin D(CD) in the tissue of breast cancer and benign lesion,then clarify the relationship between the results and the correlated histological grade,axillary lymph node metastasis,prognosis of the patients. Methods:The expressions of bcl-2, p53 and CD in 86 cases of breast cancer and 33 cases of benign lesion were observed by S-P immunohistochemical method. Results: Inverse correlation was found between the expression of bcl-2 and p53( P 0. 05). The expressions of bcl-2 and p53 were significant with histological grade ( P 0.05). bcl-2 was more frequently detected in well differentiated carcinomas while p53 was more frequently expression in poorly differentiated carcinomas. The expression of CD was not related to histological grade( P 0. 05). The expressions of p53,CD were positively related to axillary lymph node metastasisC P0. 05) while the expression of bcl-2 was not related to the metastasis( P0. 05). Conclusion: bcl-2,p53 and CD may be used as histological grade,axillary lymph node metastasis and prognosis indicators in breast cancer." @default.
- W2381781189 created "2016-06-24" @default.
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- W2381781189 date "2005-01-01" @default.
- W2381781189 modified "2023-09-28" @default.
- W2381781189 title "Clinical significance of bcl-2, p53 and cathepsin D in breast cancer" @default.
- W2381781189 hasPublicationYear "2005" @default.
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