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- W2381787970 abstract "OBJECTIVE To explore the differences of three atypical antipsychotics on efficacy and side effects in first-episode female schizophrenic patients.METHODS 163 first-episode female schizophrenic patients were randomly recruited into resperidone,quetiapine and aripiprazole group and treated for 8 weeks respectively.Clinical efficacy and side effects were assessed by PANSS and TESS scale.Meanwhile,serum prolactine,serum lipids and body weight were measured before and after treatment.RESULTS PANSS scores in three groups significantly decreased than that before treatment after 8 weeks(P≤0.05),but there were no markedly differences of PANSS scores in three groups(p0.05) after 8 weeks treatment.There were no severe side effects in three atypical antipsychotics,but there were more menstruate disturbance and elivated prolactine in risperidone group than that in quetiapine and aripiprazole group(P0.05).There was more sedation and dizzy in quetiepine group.There were more insomina,dry mouth,exciting and vomiting in aripiprazole group.Elivated serum triglycerides in quetiepine group was more than resiperidone group(P0.05).There was little affections on serum triglycerides and cholesterol in aripiprazole group.Weight gain in aripiprazole was significantly less than that in quetiapine and resperidone group.CONCLUSION Three atypical antipsychotics were all more effectives on first-episode female schizophrenic patients.But there were differences of side effects in three groups.And clinical manifestations and personal conditions should be considered when three atypial antipsychotics were used." @default.
- W2381787970 created "2016-06-24" @default.
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- W2381787970 date "2008-01-01" @default.
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- W2381787970 title "A Control Study of Three Atypical Antipsychotics on Efficacy and Side Effects in First-episode Female Schizophrenic Patients" @default.
- W2381787970 hasPublicationYear "2008" @default.
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