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- W2381790613 abstract "Fifty six healthy rabbits were randomly divided into three groups.The 8 rabbits in control group(groupⅠ) were infused with the same amount of 0 86% chloride sodium as in group Ⅱ.The 24 rabbits in endotoxin group(group Ⅱ) received endotoxin iv ET 300 μg/kg body weight to make the endotoxic shock model.After gave CA 200 mg/kg body weight,the 24 rabbits in ET+CA group(groupⅢ) were treated as groupⅡ.Blood simples were taken at 1,2,3,4,5 hour,for examination of the methylenedioxyamphetamine(MDA),total antioxidative capacity(T AOC) and catalse(CAT) in plasma.4 rabbits of group Ⅰ,12 rabbits of group Ⅱ and Ⅲ were killed,at 2,5 h,and their livers sampled quickly to assay the activities of glutathione(GSH),glutathione peroxidase(GSH Px) and the glutathione sulfurtransferase(GSH ST).The results were summarized as follows:all indexes of group Ⅰ had no significant change.The increase of MDA in group Ⅱ was significant(P0 01),the plasma MDA in group Ⅲ increased not as high as group Ⅱ,and there wasn′t significant difference between group Ⅰ and Ⅲ.Plasma CAT and T AOC of group Ⅱ decreased significantly(P0 01),and group Ⅲ decreased lower than group Ⅱ.The activities of liver GSH,GSH Px and GSH ST in group Ⅱ reduced markedly(P0 01).All indexes of group Ⅲ were higher than those in group Ⅱ,except GSH Px at 5 h.The results showed that CA can effectively counteract the injury of the lipid peroxidation by endotoxin induced free radical." @default.
- W2381790613 created "2016-06-24" @default.
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- W2381790613 date "2003-01-01" @default.
- W2381790613 modified "2023-09-25" @default.
- W2381790613 title "Protective Effects of Cation A on Free Radical Injury Induced by Endotoxin in Rabbits" @default.
- W2381790613 hasPublicationYear "2003" @default.
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