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- W2381793697 abstract "The expression of Sonic Hedgehog(Shh),Gli1 and vascular endothelial growth factor(VEGF)in the occurrence and development of colorectal cancer is not clear.The expression of Shh,Gli1 and VEGF in 78 cases of colorectal cancer and 30 cases of normal colorectal tissue was assessed by immunohisto-chemistry,and its correlation with clinicopathological factors was statistically analyzed to investigate the effect of Shh,Gli1 and VEGF proteins on colorectal cancer.The positive rates of Shh,Gli1 and VEGF were significantly higher in colorectal cancer than in normal tissue(32% vs.6.6%,71.7% vs 3.3%,76.9% vs 3.3%,P 0.O5).The expression of Shh,Gli1 and VEGF in colorectal cancer had no correlation to patients’age,tumor size,pathologic type(P 0.05),the expression of VEGF and Gli1 were correlated to lymph node metastasis and Duke stage(P 0.05),but Shh was correlated to Duke stage(P 0.05).Shh expression was positively correlated to Gli1 expression(r=0.349,P0.05).Gli1 expression was positively correlated to VEGF expression(r = 0.865,P 0.05).Shh expression was positively correlated to VEGF expression(r = 0.403,P 0.05).Shh,Gli1 and VEGF have synergetic and mutual regulation in the occurrence and development of colorectal cancer,the Shh,Gli1 and VEGF expression participate in the development,invasion and metastasis process of colorectal cancer.Their joint detection can be looked upon as an important symbol for judging the prognosis of colorectal cancer,screening the high-risk metastasis patients and guiding the therapy of colorectal carcinoma." @default.
- W2381793697 created "2016-06-24" @default.
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- W2381793697 date "2010-01-01" @default.
- W2381793697 modified "2023-09-26" @default.
- W2381793697 title "Expression of Shh,Gli1 and VEGF Proteins in Colorectal Cancer and Their Clinical Significance" @default.
- W2381793697 hasPublicationYear "2010" @default.
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