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- W2381793906 abstract "Objective Interleukin 1 (IL 1) may increase local inflammation in ischemic site and contribute to ischemic cell damage by induce expression ICAM 1 on the endothelium. The present study was designed to determinate overexpression of Interleukin 1 receptor antagonist(IL 1ra) can reduce the expression of ICAM 1 on the endothelium through transfer of adenoviral mediated IL 1ra gene after permanent focal cerebral ischemic mouse brain.Methods The construction of replication defective recombinant human adenovirus vector was used, in which the human IL 1ra gene or Eschricha Coli β galactoside (LacZ) gene was inserted in the genome of a adenovirus. Adenovirus vector(1×10 9 particle) encoding the IL 1ra gene or the LacZ gene and normal saline were injected into the right lateral cerebral ventricle of adult CD 1 mice, after five days, permanent middle cerebral antery occlusion (MCAO) was achieved for 24h using an intraluminal suture. Cerebral flow was monitored by transcranial laser Doppler flowmetry to verify the occlusion. ICAM 1 protein was quantified using Western blot analysis and localized immunohistochemistry. Inflammatory response of leukocyte infiltration was determined by histopathological examination.Results There were fewer ICAM 1 positive vessels in the ischemic cortex of the Ad.RSVIL 1ra thansfected mice than in the Ad.RSVLacZ thansfected and normal saline treated mice. Western blot analysis showed that ICAM 1 protein decreased about 50% in the Ad.RSVIL 1ra group compared to the other two groups. There were no significant differences in the numbers of positive vessels in the ischemic basal ganglia and contralateral hemisphere among the three groups.Conclusions IL 1ra overexpression can down regulate the expression of ICAM 1 and decressed inflammatory reaction in the ipsilateral cortex in ischemic mouse brain by inhibiting of IL 1 biological function." @default.
- W2381793906 created "2016-06-24" @default.
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- W2381793906 date "2001-01-01" @default.
- W2381793906 modified "2023-09-25" @default.
- W2381793906 title "Expression of ICAM-1 is Reduced in Permanent Focal Cerebral Ischemic Mouse Brain through Thansfer of Adenoviral mediated IL-1ra Gene" @default.
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