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- W2381809843 abstract "OBJECTIVE:To conduct a systematic evaluation on the efficacy and safety of vinpocetine injection for acute ischemic stroke.METHODS:The randomized controlled trials(RCTs) on vinpocetine for acute ischemic stroke was retrieved.Data collection and quality of the included RCTs were performed using Cochrane systematic evaluation method with qualified RCTs screened,then meta-analyses were conducted by using RevMan 5.0 software.RESULTS:A total of 15 RCTs involving 1 526 cases were included with 770 cases in the treatment group and 756 in the control group.The baseline data of each included RCT have comparability.Randomization was reported in all yet random digits table was used in only 1 case.The blinding method and allocation concealment were unreported.The studies in which there was report of endpoint indicator were failed to be retrieved.Mata-analysis on surrogate indicators demonstrated that there were statistical significances between vinpocetine injection and other medications or conventional therapy in effective rate(OR=2.58,95%CI=1.96-3.40) and in the improvement of neurologic impairment scores(WMD=1.58,95%CI=1.13-2.02).The adverse drug reaction was extremely less frequent and mild thus vinpocetine injection was safe to use.CONCLUSION:The systematic evaluation on vinpocetine injection revealed that vinpocetine is quite effective for acute ischemic stroke and it can improve the nerve dysfunction.This conclusion should be treated with caution because of the poor quality of the included RCTs which may impact the power of the proof.More randomized double-blind control trials with high quality are needed to provide high-quality evidence." @default.
- W2381809843 created "2016-06-24" @default.
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- W2381809843 date "2013-01-01" @default.
- W2381809843 modified "2023-09-25" @default.
- W2381809843 title "Vinpocetine Injection for Treatment of Acute Ischemic Stroke:A Systematic Review" @default.
- W2381809843 hasPublicationYear "2013" @default.
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