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- W2381824709 abstract "OBJECTIVE To investigate the effects of rhein on neuropeptide Y (NPY) and its receptors Y1R,Y2R expressions in the renal tissue of streptozotocin (STZ)-induced diabetic rats.METHODS After the diabetic rat models were induced by intraperitoneal injection of STZ,the diabetic rats were randomly divided into non-treatment group (DM),treatment group with rhein(DM-T),and the normal non-diabetic rats were served as the normal control group (NC),twelve rats in each group.Rhein was administrated orally in the treatment group with rhein (100 mg·kg-1·d-1),and the other two groups were administrated with comparative solvent for 10 weeks.The concentration of NPY was measured by radioimmunoassay.The mRNA expression of NPY and its receptors Y1R and Y2R were determined by real-time PCR.Protein expression of NPY receptors Y1R and Y2R were detected by Western blot.RESULTS Not only the elevated levels of fasting plasma glucose,TG,TC,24 h urinary protein excretion but also the glomerular pathological change in the diabetic rats were attenuated by rhein(P0.01).The increased expressions of NPY in hypothalamic and renal tissues in STZ-diabetic rats were reduced by the treatment of rhein(P0.01),and the increased mRNA and protein levels of NPY receptors Y1R and Y2R in the kidney of diabetic rats were also attenuated by rhein(P0.05).CONCLUSION Rhein shows an anti-diabetic property accompanied with amelioration of diabetic nephropathy in STZ-induced rats.The mechanism may be related with ameliorating the abnormality expression of NPY and its receptors Y1R and Y2R." @default.
- W2381824709 created "2016-06-24" @default.
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- W2381824709 date "2010-01-01" @default.
- W2381824709 modified "2023-09-26" @default.
- W2381824709 title "Effects of Rhein on Neuropeptide Y and Its Receptors Y1R,Y2R Expressions in Renal Tissue of Streptozotocin-Induced Diabetic Rats" @default.
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