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- W2381831572 abstract "GSTPi is expressed by miscellaneous human malignancies at high level. Overexpresssion of GSTPi in malignant tissue combined with its expression in preneoplastic and neoplastic lesions has been used to argue that GSTPi is a diagnostic marker, but this has not been widely accepted yet. Moreover, GSTPi has been found to relate to tumor drug resistance. In this study, 36 pancreatic adenocarcinomas, 15 lymph node metastatic samples from the above malignancies, 10 chronic pancreatitis and 12 normal pancreatic samples were examined immunohistochemically for expression of GSTPi. No significant difference of GSTPi expression has been found between non - tumor samples (including normal pancreas and chronic pancretitis) and malignant samples (P0.5). GSTPi is expressed by primary pancreatic cancers at markedly higher level than corresponding metastatic lesions in lymph nodes (F0.001). Compared by Kaplan -Meire's curve and Log-rank test, pancreatic adenocarcinomas with negative GSTPi staining have a better prognosis than positive ones. Thus, we conclude that expression of GSTPi cannot be used as a tumor diagnostic marker. Discrepancy of sensitivity to chemotherapy may exist between primary and metastatic lesions of pancreatic cancers. Expression of GSTPi in pancreatic cancers can be used as a marker of prognosis." @default.
- W2381831572 created "2016-06-24" @default.
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- W2381831572 date "1996-01-01" @default.
- W2381831572 modified "2023-09-23" @default.
- W2381831572 title "Expression of GSTPi in Normal Pancreas, Chronic Pancreatitis and Malignant Pancreas:an Immunohistochemical Study" @default.
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