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- W2381848637 abstract "BACKGROUND OBJECTIVE: Multidrug resistant (MDR) cells can resis t drug-induced apoptosis, which is the functional mechanism for many chemotherape utic drugs. It is necessary to search for the molecular mechanism underlying ant i-apoptosis of MDR cells. However, because of the anti-apoptosis characteristi c of MDR cells, it is hard to study the mechanism on their apoptosis pathway. Th is study was to induce apoptosis in human acute leukemia cell line HL-60, and i ts MDR cell lines HR20 and HT9 by cyclosporin A (CsA), analyze the differences i n apoptosis pathway between MDR cells and sensitive cells by detecting several i mportant apoptosis-related molecules. METHODS: HL-60, HR20, and HT9 cells were treated with 10, and 20 mg/L of CsA, cell apoptosis was identified by cell morp hologic changes,electrophoresis,and flow cytometry. Changes of apoptosis-relate d factors were detected by spectrophotometer and Western blot. RESULTS: HL-60, HR20, and HT9 cells all showed obvious apoptotic characteristics after treated w ith CsA,such as chromatin condensation, DNA fragmentation factor (DFF) degradati on and activation, and DNA fragmentation. However, Caspase-3 activation was onl y detected in apoptotic HL-60 cells. CONCLUSIONS: CsA may induce apoptosis of H R20, and HT9 cells in a Caspase-3 independent manner, which is different from a poptosis of sensitive cells. In the apoptosis pathway of HR20, and HT9 cells, th ere may be some factors other than Caspase-3 that can activate DFF. It is postu lated that the difficulty of Caspase-3 to be activated may be an important reas on for HR20 and HT9 cells to resist apoptosis induced by many chemotherapeutic d rugs." @default.
- W2381848637 created "2016-06-24" @default.
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- W2381848637 date "2004-12-01" @default.
- W2381848637 modified "2023-09-23" @default.
- W2381848637 title "Inducing effect of cyclosporin A on apoptosis of multidrug resistant cell lines HR20 and HT9" @default.
- W2381848637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15601549" @default.
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