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- W2381866455 abstract "ObjectiveTo explore the preventive and therapeutic effec t of γ-interferon to experimental silicosis by studying the effect of γ-interf eron on lung/body coefficient and hydroxyproline in rats exposed to quartz dust.MethodsFemale Wistar rats were exposed to lower dose (20 mg/rat) of quartz dust by intratracheal injection.Beginning from the second day ,the experimenatal rats were treated with γ-interferon (1×10 5IU/rat) daily.R ats were killed after 1 and 2 month.Changes of lung/body coefficient and lung hy droxyproline content were determined.ResultsThe lung/body coefficient showed no significant difference between quartz control groups and treated groups.The lung hydroxyprol ine of treated groups were significantly lower than that of quartz control group s (P0 05).Conclusionγ-interferon could significanlty reduc e lung hydroxyproline content of quartz exposed rats.This denoted that γ-interf eron may inhibit or delay early silicotic fibrosis." @default.
- W2381866455 created "2016-06-24" @default.
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- W2381866455 date "2004-01-01" @default.
- W2381866455 modified "2023-09-26" @default.
- W2381866455 title "Effect of γ-interferon on lung silicosis of rats exposed to quartz dust" @default.
- W2381866455 hasPublicationYear "2004" @default.
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