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- W2381874631 abstract "Objective To discuss the preliminary clinical result of targ et volum e delineation for radiotherapy of nasopharyngeal carcinoma(NPC). Methods From Jun e 2001 to March 2003, 81 NPC patients were studied:4 Stage Ⅰ,23 Ⅱ,35 Ⅲ,and 19 Ⅳa lesion,according to the Fuzhou 1992 Stage Classification System. Forty-thr e e patients were treated with radiotherapy alone, whereas 38 patients had radioth erapy combined with cisplatin-based chemotherapy. The target volume was describ ed as: the gross tumor volume of the nasopharynx (GTVnx) ,the cervical lymph no de (GTVnd), the clinical volume (CTV1), and the clinical volume 2 (CTV2) , resp ectively. The planning target volume(PTV), defined as the GTV or CTV plus a marg in, were PTVnx, PTVnd, PTV1 and PTV2 . The prescribed dose to the PTVnx, PTVnd, PTV1 and PTV2, were 60-76?Gy, 62-66?Gy, 60?Gy, and 50-52?Gy, respectively . The irra diation field was reduced step-by-step basing on the different planning target v olume. Eight patients with different stages were chosen to evaluate the dose dis tribution to the target volume on 3D planning system before the treatment. The l ocoregional progression-free, distant metastasis-free rate and overall surviva l rate were calculated by Kaplan-Meier statistical method. Resu lts The dose-vo lu me histogram analysis revealed that less than 9% of the average of the planning target volume received 95% of the prescribed dose. Local and regional residual tumor was observed in four patients, 2 in the GTVnx and 2 in the GTVnd.Its locor egional control rate was 97.5%. With a median follow-up of 15 months (range 9- 3 0 months), no local or region control failure was found in all patients. The loc oregional progression-free rate, distant metastasis-free rate, and overall sur v ival rate in two years were 100.0%, 96.3%, and 100.0% respectively. Conclusions S atisfiedactory locoregional control can be achieved by our method of defining th e target volume and radiation technique with no recurrent tumor observed inside, outside, or marginal to the target volume. Further study should be warranted to verify the rationality and accuracy of our understanding and endeavor in the ta rget volume in this study." @default.
- W2381874631 created "2016-06-24" @default.
- W2381874631 creator A5049485801 @default.
- W2381874631 date "2005-01-01" @default.
- W2381874631 modified "2023-09-25" @default.
- W2381874631 title "Initial study of the clinical target volume delineation for radiotherapy of nas opharyngeal carcinoma" @default.
- W2381874631 hasPublicationYear "2005" @default.
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