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- W2381882938 abstract "Objective To investigate the effects of propofol on extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in mouse hippocampal slices.Methods BALB/C mice of both sexes weighing 18-22 g were quickly decapitated and hippocampus was immediately isolated on ice and cut into slices to a thickness of 450μm using MacⅡwain tissue chopper. In the concentration-response relationship experiment the slices were incubated with different concentrations of propofol 10-4,10-5,10-6,10-7,10 and 10-9 mmol·L-1 at 36℃for 1 h. In time-response experiment hippocampal slices were incubated with propofol 5 mmol·L-1 for 0, 1, 2, 5, 7, 9, 12, 15, 30, 60 min respectively. After being incubated for 5 min some slices were collected and placed in plain artificial CSF for 2, 4, 7, 10, 25 min to wash out propofol. Phosphorylation of ERK1/2 in hippocampal slices was examined by immunoblotting with both phosphor-p44/42 Map kinase antibodies. Results Propofol decreased phosphorylation of ERK1/2. The decrease was time- and concentration-dependent. The washout of propofol resulted in an increase in ERK1/2 phosphorylation. Conclusion Propofol markedly decreases phosphorylation of ERK1/2 in mouse hippocampal slices." @default.
- W2381882938 created "2016-06-24" @default.
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- W2381882938 date "2006-01-01" @default.
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- W2381882938 title "Effects of propofol on extracellular signal-regulated kinase1/2 phosphorylation in mouse hippocampal slices" @default.
- W2381882938 hasPublicationYear "2006" @default.
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