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- W2381888045 abstract "Objective To detect the metabolite of thalamus,basal ganglia,insular lobe of patients with idiopathic generalized tonic clonic seizure(GTCS) and to discuss the role and significance of the change in the onset of GTCS.Methods There were twenty patients of idiopathic GTCS,two-sides metabolites of thalamus basal ganglia,insular lobe were collected by magnetic resonance spectroscopy(MRS),and N-aceytl aspartate(NAA),creatine(Cr),choline(Cho)were conducted with half-quantitative analysis.Amalgamated the colour-coded imaging which relative signal intensity of metabolites and TIRT1 imaging,to measure NAA/(Cho+Cr) singal intensity in thamalus basal ganglia,insular lobe areas.The distribution of metabolites in thalamus was analyzed straightly.Results The both NAA/Cr levels of thalamus in the GTCS group were significantly lower.The ratio of NAA/(Cr+Cho) was either lower than that of the normal control group(P0.05),but there was no difference between the two groups in basal ganglia and insular lobe.Through the amalgamation of the colour-coded imaging and the routine MRI imaging,the difference of the signal intensity of the ratio of NAA/(Cho+Cr) in thalamus between two groups could be straightly detected.Conclusion The common pathology of idiopathic GTCS is the loss of neuron and hyperplasia of colloid cell.The abnormality NAA/(Cho+Cr) of thalamus in idiopathic GTCS may indicate a correlated encephalic region of the form of epilepsy or injured cerebral zone caused by long time epileptic seizures." @default.
- W2381888045 created "2016-06-24" @default.
- W2381888045 creator A5006167598 @default.
- W2381888045 date "2007-01-01" @default.
- W2381888045 modified "2023-09-24" @default.
- W2381888045 title "Clinical significance of magnetic resonance spectroscopy of idiopathic generalized tonic clonic seizure epilepsy" @default.
- W2381888045 hasPublicationYear "2007" @default.
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