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- W2381897836 abstract "Objective:This study was aimed to explore the feasibility and effects of human cord blood cell transplantation for the treatment of premature ovarian failure(POF) in nude mices.Methods:Thirty female nude mouse were randomly divided into three groups,Normal control group(n=35) and premature ovarian failure(POF plus vehicle,n=35);POF plus cell transplantation(HCMNCs were implanted into the bilateral ovarian,n=35).Cobalt-60 irradiation was used to establish POF models.HCMNCs were isolated by ficoll density gradient centrifugation,and labled by BrdU.Four weeks after transplantation,the nude mice were sacrificed for determination of serum E2,FSH,LH,histological and immunochemical examination of the bilateral ovaries.Results:The transplanted HCMNCs survived in transplantation group and participated the repair process in ovaries.The serums of E2,FSH,LH of the transplantation group were compared with POF control group.E2 significantly increased(P0.05),FSH decreased significantly(P0.05),LH decreased significantly(P0.05).And also found the number of follicles recovered.Conclusions:HCMNCs can be successfully transplanted into nude mice ovaries,and can improve the recovery of ovarian function." @default.
- W2381897836 created "2016-06-24" @default.
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- W2381897836 date "2012-01-01" @default.
- W2381897836 modified "2023-09-23" @default.
- W2381897836 title "Human Cord Blood Mononuclear Cell Transplantation in the Treatment of Radioactive Experimental Study of Premature Ovarian Failure in Nude Mice" @default.
- W2381897836 hasPublicationYear "2012" @default.
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