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- W2381915231 abstract "Objective To explore the differential diagnosis of pulmonary carcinoids and small cell lung cancer(SCLC) in bronchoscopically biopsied specimens.Methods We analyzed 7 cases of pulmonary carcinoids misdiagnosed as SCLC in bronchoscopically biopsied specimens.Bronchial biopsies from 9 cases of SCLC were used as control group for histologic and immunohistochemical studies.Results The pulmonary carcinoids presented as either central or peripheral lesions composed of tumor cells with granular,sometimes coarse chromatin pattern,high levels of chromogranin A/synaptophysin immunoreactivity,and low(20%) Ki-67 labeling index.SCLC always showed central tumor location,finely dispersed nuclear chromatin,lower levels of chromogranin A/synaptophysin,and high(50%) Ki-67 labeling index.Conclusion Misdiagnosis of pulmonary carcinoids as SCLC in small crushed bronchial biopsies remains a significantly potential problem in medical practice.The evaluation of tumor cell proliferation by Ki-67 labeling index may be the most useful ancillary technique for the distinction." @default.
- W2381915231 created "2016-06-24" @default.
- W2381915231 creator A5064816551 @default.
- W2381915231 date "2010-01-01" @default.
- W2381915231 modified "2023-09-23" @default.
- W2381915231 title "Pathological Diagnosis of Pulmonary Neuroendocrine Carcinoma in Biopsy Specimens" @default.
- W2381915231 hasPublicationYear "2010" @default.
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