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- W2381915858 abstract "Objective:To observe the changes of urine NGAL(neutrophil gelatinase-associated lipocalin),IL-18,and KIM-1(kidney injury molecule-1) in earthquake-caused crush syndrome(CS) patients with acute kidney injury(AKI) on continous renal replacement therapy(CRRT). Methodology:Sixteen patients with crush syndrome in Wenchuan Earthquake receiving CRRT therapy were enrolled in this research,and 10 patients were followed up for 14 days,the control were 12 healthy volunteers.The blood samples and urine samples were obtained from both groups.The urinary levels of IL-18,KIM-1 and NGAL were measured by ELISA techniques.Other parameters such as urine creatine,serum creatine,serum myoglobin,urine myoglobin,serum creatinekinase and serum potassium were measured at the same time.ATN-ISI' was applied to evaluate the severity and prognosis of AKI.Independent t-test was applied to compare the difference of age,serum creatine,urine myoglobin,urine NGAL,urine KIM-1,and urine IL-18 between the experimental group and the control.Paired t-test was applied to compare the changes of urine NGAL,KIM-1,and IL-18 between day 1 and day 14 we observed.Pearson's test was applied to study the correlation between ATN-ISI' and the urine markers of IL-18,NGAL,and KIM-1. Results:There was no difference of age(40.0±21.4 vs 34.2±6.7,P0.05) between the CS group and the control.Serum creatine(324±189 μmol/L vs 72.1±15.7 μmol/L,P0.01),urine myoglobin(594±381ng/ml vs 8.70±1.70ng/ml,P0.01),urine IL-18(59.5±41.3 μg/g vs 22.62±17.40 μg/g,P0.01),urine NGAL(1.06±1.07 μg/g vs 0.39±0.30 μg/g,P0.05),and urine KIM-1(1.87±1.47 μg/g vs 0.92±0.62 μg/g,P0.05) was higher in the CS group compared with the control.Pearson's test showed a positive correlation among urine KIM-1,NGAL,and IL-18,P0.001.NGAL showed a positive correlation with ATN-ISI(r=0.65,P0.01).Urine NGAL(0.86±0.51 μg/g,0.78±0.64 μg/g)(P0.05),IL-18(57.3±36.9 μg/g,97.1±119 μg/g)(P0.05),and KIM-1(1.78±1.61 μg/g,1.77±1.55 μg/g)(P0.05) showed slight change from day 1 to day 14.3 patients have recovered from hemodialyis,in these patients the urinary NGAL(1.14±0.54 μg/g,0.37±0.23 μg/g),KIM-1(3.01±1.54 μg/g,0.75±0.52 μg/g),and IL-18(71.7±30.3 μg/g,24.1±12.2 μg/g) decreased with the concentrations close to the control on day 14. Conclusion:Urine AKI markers such as IL-18,NGAL,and KIM-1 increases in earthquake-caused crush syndrome patients with acute renal failure.Urine NGAL may predict the severity of kidney injury,these markers decrease with the recovery of kidney injury." @default.
- W2381915858 created "2016-06-24" @default.
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- W2381915858 date "2009-01-01" @default.
- W2381915858 modified "2023-09-23" @default.
- W2381915858 title "Urine markers of acute kidney injury in patients with quake-associated crush syndrome" @default.
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