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- W2381917174 abstract "Objective To explore the intervene effect of Shenxinning Prescription on ventricular remodeling in AT1-KO rats with chronic renal insufficiency.Methods Establish the models by cutting off 5/6 kidney in AT1-KO rats,treated with Shenxinning Prescription for 12 weeks,and compared with simple nephrectomy rats.The BUN,Scr,BNP,LVDD,LVDS,FS,EF,changes of myocardium and ultra micro structure were observed.Results Shenxinning Prescription can decrease the BUN,SCR,LVDD,LVDS and BNP,and increase the FS and EF to improve the quatity and structure of mitochondria.Conclusion ① RASS system plays an important role in ventricular remodeling of chronic renal insufficiency,RASS antagonism can improve the ventricular remodeling;②Shenxinning Prescription is effective to improve the kidney function of CRF,and has synergic action with RASS antagonism;③Shenxinning Prescription is effective to improve the ventricular remodeling of CRF,and the mechanism is related to RASS improvement,uremic toxin reduction and improvement of myocardial ultra micro structure." @default.
- W2381917174 created "2016-06-24" @default.
- W2381917174 creator A5010803737 @default.
- W2381917174 date "2012-01-01" @default.
- W2381917174 modified "2023-09-23" @default.
- W2381917174 title "Experiment research on intervene effect of Shenxinning Prescription on ventricular remodeling in AT1-KO rats with chronic renal insufficiency" @default.
- W2381917174 hasPublicationYear "2012" @default.
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