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- W2381922379 abstract "Objective To discuss the parallelism of signals in MR diffusion-weighted imaging(DWI) and metabolic abnormity in proton MR spectroscopy(~1HMRS) with pathologic and biochemical changes in adrenoleukodystrophy (ALD). Methods DWI and ~1H MRS examination were performed in 6 cases with ALD proven by serum VLCFA, comparing ADC and relative ratio values of each metabolite in different regions of lesion with normal white matter.Results Initial lesions in occipital-parietal lobes showed very low signals on DWI and the highest ADC values(2.400×10~ -3 mm~2/s,F=7.31,P=0.003), the ratios of NAA/Cr and NAA/Cho were lower(0.62±0.24,F=4.00,P=0.02; 0.32±0.16,F=6.75,P=0.02),and Cho/Cr and Lac/Cr were higher than normal white matter(1.96±0.53,F=3.53,P=0.03; 0.28±0.24,F=3.22,P=0.04). On expanding regions to frontal lobe, the signal became highest and ADC values was lowest[(0.749-0.752)×10~ -3 mm~2/s,F=7.31,P=0.003].The depressed tendency of NAA/Cr and NAA/Cho in adjacent lesion was distinct than that of remote lesion (q_2=-0.23,P_2=0.047; q_2=-0.23,P_2=0.02). There was no significant difference in the increase of Cho/Cr and Lac/Cr ratios (q_2=0.34,P_2=0.19; q_2=0.11,P_2=0.17).Conclusion MRS offers a useful method for dynamic observation of spatio-temporal changes in ALD. ADC values and choline, lactic acid levels increase in obsolete lesions whereas NAA levels decrease distinctly. In expanding lesion, ADC values decrease markedly, while the elevation of Choline and Lactic acid is not significant in adjacent region. NAA levels decrease moderately because of remnant neuron and axon." @default.
- W2381922379 created "2016-06-24" @default.
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- W2381922379 date "2005-01-01" @default.
- W2381922379 modified "2023-09-25" @default.
- W2381922379 title "Analysis of functional MR imaging patterns in adrenoleukodystrophy" @default.
- W2381922379 hasPublicationYear "2005" @default.
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