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- W2381926932 abstract "Objective:To investigate the effects of Xiaochaihu Decoction on damage of gut-liver-brain in CCl4/ethanol-induced mouse hepatocellular carcinoma.Method:Hepatocellular carcinoma group(HCC) were induced by subcutaneous injection with 25% CCl4 olive oil solution(5 mL · kg-1 twice per week) and allowed free access to a 8% ethanol solution as drinking fluid for 4 weeks,and allowed free access to 0.5% CCl4-8% ethanol solution as drinking fluid for 20 weeks;in HCC combined with liver depression and spleen deficiency(LDSD) group(HCC-LDSD group),on the basis of HCC modelling,the mice were stimulated with the factor of LDSD,squeezing tails(30 min·d-1),solitary breeding and intermittent fasting for 4 weeks,solitary breeding and intermittent fasting for 20 weeks;Xiaochaihu decoction(XCHD) treated group was administered by gavage for 8 weeks after 4 weeks of the HCC-LDSD modelling.The mortality rates and HCC incidence rates were calculated,weight and clinical signs were monitored daily.The degree of tissue injuries in the gut and liver were studied using a scoring system,and brain weights were measured.Result: The mortality rate in HCC-LDSD group was higher than that in the HCC group,after treatment with XCHD,the mortality rate decreased significantly.In death mouse of HCC group,significantly more injuries in small intestine,cecum,liver and fecal loading in the cecum,with the increased in brain weights,the most in HCC-LDSD group,after treatment with XCHD,all of which were improved.HCC incidence rate in the HCC-LDSD group was higher than that in the HCC group,after treatment with XCHD,the HCC incidence rate decreased significantly.In survival mouse of HCC group,significantly more injuries in small intestine,cecum,liver(mainly hyperplasia),with slight decreased in brain weights,the most in HCC-LDSD group,after treatment with XCHD,all of which were improved.Correlative analysis showed that there was a positive or negative correlation between small intestine injuries,cecum injuries,fecal loading in the cecum,liver injuries and brain weights in death mouse and survival mouse.Conclusion: XCHD offered protection against CCl4/ethanol-induced inflammation by decreased the injury of gut-liver-brain,and improved gut-liver-brain interactions,and ultimately decreased mortality rates and HCC incidence rates in CCl4/ethanol-induced mouse HCC,it need further research to understand the molecular mechanism of effects of XCHD." @default.
- W2381926932 created "2016-06-24" @default.
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- W2381926932 date "2012-01-01" @default.
- W2381926932 modified "2023-09-23" @default.
- W2381926932 title "Effects of Xiaochaihu Decoction on Damage of Gut-liver-brain in CCl_4/Ethanol Induced Mouse Hepatocellular Carcinoma" @default.
- W2381926932 hasPublicationYear "2012" @default.
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