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- W2381927776 abstract "Objective:To observe the effects of Aralia echinocaulis Hand-Mazz in Guizhou on adjuvant arthritis in rats and discuss the mechanism.Method: Rats were divided into normal control group,model group,positive drug group(tripterygium wilfordii 12 mg·kg-1),A.echinocaulis high dosage group,middle dosage group,low dosage group(the dosage 3.5,1.75,0.88 g·kg-1)randomly,all rats were made into ovalbumin adjuvant-induced arthritis model in Freund's adjuvant(FCA) except the normal group.The according treatments were given by oral gavage for each group starting from the modeling day,then continuously for 35 days.The effect on rats' primary and secondary adjuvant-induced arthritis were observed.Nitric oxide(NO) content in serum was detected by nitrate reductase method and the interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α) were measured with radioimmunoassay(RIA).Result:A.echinocaulis had obvious inhibition on rats' ankle adjuvant-induced arthritis,the inhibitory effect was decreased with the alleviation of the amount of dosage(middle dosage group,low dosage group).The A.echinocaulis high dosage group could decrease the IL-1 level in rat serum significantly.The high and middle dosage group could decrease the TNF-α level significantly.The high,middle and low dosage group could decrease the NO level significantly.From the pathological observation,the rat ankle joint inflammatory cells in A.echinocaulis high dosage group decreased obviously,the synovial membrane tissue cells and the fibroblast cells did not increase obviously,the articular cartilages got few failure.Conclusion: The high dosage A.echinocaulis is effective in the treatment of AA rats by inhibiting the inflammatory cytokines." @default.
- W2381927776 created "2016-06-24" @default.
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- W2381927776 date "2011-01-01" @default.
- W2381927776 modified "2023-09-25" @default.
- W2381927776 title "Effects ofAralia echinocaulis in Guizhou on Adjuvant Arthritis in Rats and Related Mechanism" @default.
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