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- W2381946108 abstract "Mice, infused with 2.8 μg of colchicine in 0.5 μL of saline into each hippocampus, have been shown a significant increase in the error numbers and a decrease in the latency in step down and step through tests fourteen days after the infusion. At the same time there was also a significant decrease in cAMP levels in the cortex and hippocampus. CGP36742(3 aminopropyl n butyl phosphinic acid), a GABA B receptor antagonist, at the dosage of 50 mg·kg 1 ip daily for 14 d, could attenuate the impairment of learning and memory and the decrease in cAMP levels in the mice treated by colchicine. Being used for 14 d after infused with saline in each hippocampus, CGP36742 could also improve learning and memory function and elevate cAMP levels in the cortex, hippocampus and cerebellum. The results suggest that the elevation of cAMP levels in the brain could be beneficial to learning and memory functions and GABA B receptor antagonist might be a novel type of drug to treat Alzheimer′s disease." @default.
- W2381946108 created "2016-06-24" @default.
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- W2381946108 date "1997-01-01" @default.
- W2381946108 modified "2023-09-25" @default.
- W2381946108 title "Effect of hippocampal microinfusion of colchicine on learning and memory, and protective function of CGP36742 in mice" @default.
- W2381946108 hasPublicationYear "1997" @default.
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