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- W2381948511 abstract "To investigate the frequency distribution of vitamin D receptor(VDR) genotype in Chinese population and evaluate the correlation between VDR gene polymorphisms and bone mineral density(BMD). Methods Polymerase chain reaction (PCR) and restriction analysis were used to determine VDR genotypes in 148 Chinese women. Their L_2－4 lumbar spine BMD was measured by dual - energy X - ray absorptiometry (DEXA). Results The frequency distribution of the VDR genotype was: BB, 2. 7%; Bb, 8. 1%; bb, 89. 2%. The BMD in perimenopasal women of different genotypes were (1. 123 ± 0. 105 ) g/cm~2 (BB), (1. 290 ±0. 141 ) g/cm~2 (Bb) and (1. 185 ±0. 130) g/cm~2 (bb) respectively. The BMD was significantly lower in postmenopausal women than perimenopausal women (P 0. 01). The incidence of osteoporosis in postmenopausal women was 34%. Conclusion The frequency distribution of the VDR genotype in Chinese peri － and postmenopausal women were apparently different from that in Western countries. The correlation between the VDR genotype and BMD was not found." @default.
- W2381948511 created "2016-06-24" @default.
- W2381948511 creator A5069973255 @default.
- W2381948511 date "2000-01-01" @default.
- W2381948511 modified "2023-09-25" @default.
- W2381948511 title "An analysis of the correlation between vitamin D receptor gene polymorphisms and bone mineral density" @default.
- W2381948511 hasPublicationYear "2000" @default.
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