Matches in SemOpenAlex for { <https://semopenalex.org/work/W2381961496> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2381961496 abstract "AIM: To evaluate the effects of rosuvastatin on inflammation of myocardial tissues in rats with acute myocardial infarction(AMI).METHODS: Twenty male Wistar rats with ligated LAD were used to establish models of AMI and the successfully established models were randomly divided into acute myocardial infarction group(AMI group) and rosuvastatin intervention group(ROS group).Another 10 rats(sham group) were tested with pierced but not ligated LAD.Rats in ROS group were given rosuvastatin by gavage at 10 mg/(kg·day) dose levels,whereas rats in the other two groups were given 2 ml normal saline each day.Four weeks later,noninfarcted myocardial tissues were observed with HE section staining,whereas NF-κB and IL-6 were detected by immunohistochemistry and RT-PCR.RESULTS: HE section staining showed that cardiac tissues were more orderly arrayed.There was less rupture of cardiac tissue fiber,less fibrosis,and the inflammatory cell reaction was milder in the ROS group compared with rats in the AMI group.No expressions of NF-κB and IL-6 were found in sham group.In AMI group,both mRNA expression and protein production of these cytokines were markedly higher than those in sham group(P0.05).Significant reductions of mRNA expression and protein production of NF-κB and IL-6 were observed in ROS group compared with those in AMI group(P0.05),NF-κB and IL-6 of the two were positively correlated(r=0.85,0.78).CONCLUSION: Rosuvastatin helps regulate the activation of NF-κB and reduces the expression of IL-6 in AMI rat;therefore,it is beneficial to the ventricular remodeling improvement." @default.
- W2381961496 created "2016-06-24" @default.
- W2381961496 creator A5088618008 @default.
- W2381961496 date "2011-01-01" @default.
- W2381961496 modified "2023-09-27" @default.
- W2381961496 title "Effects of rosuvastatin on expressions of NF-κB and interleukin-6 in rats with acute myocardial infarction" @default.
- W2381961496 hasPublicationYear "2011" @default.
- W2381961496 type Work @default.
- W2381961496 sameAs 2381961496 @default.
- W2381961496 citedByCount "0" @default.
- W2381961496 crossrefType "journal-article" @default.
- W2381961496 hasAuthorship W2381961496A5088618008 @default.
- W2381961496 hasConcept C11988809 @default.
- W2381961496 hasConcept C126322002 @default.
- W2381961496 hasConcept C134018914 @default.
- W2381961496 hasConcept C164027704 @default.
- W2381961496 hasConcept C164705383 @default.
- W2381961496 hasConcept C204232928 @default.
- W2381961496 hasConcept C2776914184 @default.
- W2381961496 hasConcept C2777397205 @default.
- W2381961496 hasConcept C2777785397 @default.
- W2381961496 hasConcept C2778690821 @default.
- W2381961496 hasConcept C2780499067 @default.
- W2381961496 hasConcept C2780559512 @default.
- W2381961496 hasConcept C2780678043 @default.
- W2381961496 hasConcept C3018763269 @default.
- W2381961496 hasConcept C500558357 @default.
- W2381961496 hasConcept C71924100 @default.
- W2381961496 hasConcept C74172505 @default.
- W2381961496 hasConceptScore W2381961496C11988809 @default.
- W2381961496 hasConceptScore W2381961496C126322002 @default.
- W2381961496 hasConceptScore W2381961496C134018914 @default.
- W2381961496 hasConceptScore W2381961496C164027704 @default.
- W2381961496 hasConceptScore W2381961496C164705383 @default.
- W2381961496 hasConceptScore W2381961496C204232928 @default.
- W2381961496 hasConceptScore W2381961496C2776914184 @default.
- W2381961496 hasConceptScore W2381961496C2777397205 @default.
- W2381961496 hasConceptScore W2381961496C2777785397 @default.
- W2381961496 hasConceptScore W2381961496C2778690821 @default.
- W2381961496 hasConceptScore W2381961496C2780499067 @default.
- W2381961496 hasConceptScore W2381961496C2780559512 @default.
- W2381961496 hasConceptScore W2381961496C2780678043 @default.
- W2381961496 hasConceptScore W2381961496C3018763269 @default.
- W2381961496 hasConceptScore W2381961496C500558357 @default.
- W2381961496 hasConceptScore W2381961496C71924100 @default.
- W2381961496 hasConceptScore W2381961496C74172505 @default.
- W2381961496 hasLocation W23819614961 @default.
- W2381961496 hasOpenAccess W2381961496 @default.
- W2381961496 hasPrimaryLocation W23819614961 @default.
- W2381961496 hasRelatedWork W2113988568 @default.
- W2381961496 hasRelatedWork W2349109708 @default.
- W2381961496 hasRelatedWork W2352607531 @default.
- W2381961496 hasRelatedWork W2360865741 @default.
- W2381961496 hasRelatedWork W2361389045 @default.
- W2381961496 hasRelatedWork W2363962732 @default.
- W2381961496 hasRelatedWork W2370712585 @default.
- W2381961496 hasRelatedWork W2374259701 @default.
- W2381961496 hasRelatedWork W2378931951 @default.
- W2381961496 hasRelatedWork W2380935572 @default.
- W2381961496 hasRelatedWork W2384382552 @default.
- W2381961496 hasRelatedWork W2387744998 @default.
- W2381961496 hasRelatedWork W2390663989 @default.
- W2381961496 hasRelatedWork W2442667033 @default.
- W2381961496 hasRelatedWork W2980470604 @default.
- W2381961496 hasRelatedWork W3005591465 @default.
- W2381961496 hasRelatedWork W3029281399 @default.
- W2381961496 hasRelatedWork W3029915283 @default.
- W2381961496 hasRelatedWork W3032503683 @default.
- W2381961496 hasRelatedWork W870710445 @default.
- W2381961496 isParatext "false" @default.
- W2381961496 isRetracted "false" @default.
- W2381961496 magId "2381961496" @default.
- W2381961496 workType "article" @default.