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- W2381974991 abstract "Objective To study the effect of maternal deprivation and chronic unpredictable stress on the behavior of the rats and the role of hippocampal microRNA let-7a in depressive-like behaviors induced by psychological stress. Methods Newborn male rats were randomly divided into four groups,maternal deprivation group( MD,n = 17),chronic unpredictable stress group( CUPS,n = 17),dual stress group( DS = MD +CUPS,n = 17) and control group( C,n = 17). MD rats only received maternal deprivation for 2 weeks right after birth,CUPS rats only received chronic unpredictable stress for 3 weeks right after 10-weeks old,DS rats received both of the maternal deprivation and chronic unpredictable stress,and Control rats received no experimental handle but regular operation. Behavior tests including open field test,forced swimming test and sucrose consumption test were carried out to evaluate rats' behaviors in the thirteen weeks after birth. Rats were rapidly decapitated after behavior tests,and tissue samples of the hippocampus were rapidly collected immediately after decapitation,and the expression level of microRNA let-7a in rat hippocampus were detected by Real-Time PCR. Results1. the result of behavior tests: 1) the interactive effect of MD and CUPS on the craw distance and vertical movement in open field test,floating time in forced swimming test and the sucrose consumption rate in sucrose consumption test was significant( P 0. 05). 2) the results of the above indices in the three experimental group were different from that of the control group( P 0. 05); 2. The expression of microRNA let-7a in hippocampus: 1)the interactive effect of MD and CUPS on the expression of let-7a in hippocampus was significant( P 0. 05),and the level of let-7a in the hippocampus of rats in MD,CUPS and DS group were 25. 21,0. 12 and 43. 62times more than that of the control group respectively. Conclusion 1. The maternal deprivation during early life stage could induce more serious anhedonia than the chronic stress during adulthood did; 2. The maternal deprivation during early life stage may be a vulnerability factor for the depressive-like behavior of rats,and the increased level of let-7a in hippocampus may be one of the sensitive markers which indicated the animal was in the vulnerable state to depression; 3. The increased expression level of let-7a in rats' hippocampus may be involved in the neurological process underlying the maternal deprivation-induced depressive-like behaviors but not in chronic stress during adulthood induced depressive-like behaviors." @default.
- W2381974991 created "2016-06-24" @default.
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- W2381974991 date "2013-01-01" @default.
- W2381974991 modified "2023-09-24" @default.
- W2381974991 title "The role ofrats' hippocampal microRNA let-7a in the depressive-like behaviors induced by psychological stress" @default.
- W2381974991 hasPublicationYear "2013" @default.
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