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- W2381986619 abstract "Objective To understand the effect of pulmonary fibrosis of rabbit treated with whole lung lavage in lung pathology.Methods Twenty-five healthy rabbits were randomed into three groups:control group(n=5),pulmonary fibrosis group(n=5),and whole lung lavage group(n=15) which consists of three subgroups(7,14,21 d group),every subgroup has five rabbits.After pulmonary fibrosis of rabbits made successfully,by injecting pingyang mycin into trachea in pulmonary fibrosis group and whde lung lavage group.the rabbits in the three subgroups were therapied with whole lung lavage in 7,14,21 days,respectively.Where as wormal saline of 2 mL injected into trachea in control group.Every rabbit died by bloodletting through abdominal aorta at the fifth weekend.After lower right lung tissue made with HE stain,reviewing the extent of pulmonary fibrosis in twenty-five rabbits according to Szapiel methods.Results Pathology of rabbit pulmonary fibrosis in three groups:there are all normal in control group;all rabbits have severe fibrosis in pulmonary fibrosis group and in 21 d subgroup;one has slight fibrosis in 7 d subgroup,the other has medium fibrosis;two have medium fibrosis in 14 d subgroup,other three have severe fibrosis.The severe extent of pulmonary fibrosis in pathology in every group:There were statistical differences in pulmonary fibrosis group,21 d and 14 d subgroups,comparing with control group(P0.01);in 7 d subgroup,comparing with control group(P0.05);and in pulmonary fibrosis group and 21 d subgroup,comparing with 7 d subgroup(P0.05).There were no statistical differences in 21 d and 14 d subgroups,comparing with pulmonary fibrosis group(P0.05).Conclusion The aggravation of pulmonary fibrosis would be delayed by whole lung lavage in the period of pulmonary alveolitis." @default.
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- W2381986619 date "2010-01-01" @default.
- W2381986619 modified "2023-09-22" @default.
- W2381986619 title "Pathology Altering of Rabbit Pulmonary Fibrosis Treated with Whole Lung Lavage" @default.
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