Matches in SemOpenAlex for { <https://semopenalex.org/work/W2381993477> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2381993477 abstract "Objective To explore the changes of glutamate receptor (GluR2) on the post-synaptic membrane, the potential mechanisms, and the effects on the delayed neuron death after oxygen-glucose deprivation (OGD). Methods The neuron death, GluR2 contents on the membrane, and the post-synaptic membrane and the paths were quantitatively observed by PI staining, colorimetric assay, and double immuno-fluorescence labeling. Results The number of delayed death neuron increased significantly after OGD. The total surface GluR2, the number of synapses with GluR2, and the quantity of GluR2 in synapse were marked lower than those in the control group (P0.05). On the contrary, the intracellular GluR2 content increased significantly. The pretreatment of hypertonic sucrose, which would block the endocytosis, inhibited the decrease of GluR2 effectively. Conclusion OGD would accelerate the endocytosis of GluR2 and induce decreased GluR2 content on the postsynaptic membrane, so the number of GluR2-lacking amino-3-hydroxy-5 methylisoxazole-4-propionic acid (AMPA) receptors may increase, which may mediate the influx of Ca 2+ and result in delayed neuron death." @default.
- W2381993477 created "2016-06-24" @default.
- W2381993477 creator A5065793748 @default.
- W2381993477 date "2004-01-01" @default.
- W2381993477 modified "2023-09-28" @default.
- W2381993477 title "Changes of GluR2 on post-synaptic membrane and its mechanisms after ischemic insult" @default.
- W2381993477 hasPublicationYear "2004" @default.
- W2381993477 type Work @default.
- W2381993477 sameAs 2381993477 @default.
- W2381993477 citedByCount "0" @default.
- W2381993477 crossrefType "journal-article" @default.
- W2381993477 hasAuthorship W2381993477A5065793748 @default.
- W2381993477 hasConcept C117277713 @default.
- W2381993477 hasConcept C127445978 @default.
- W2381993477 hasConcept C160268369 @default.
- W2381993477 hasConcept C169760540 @default.
- W2381993477 hasConcept C170493617 @default.
- W2381993477 hasConcept C185592680 @default.
- W2381993477 hasConcept C197341189 @default.
- W2381993477 hasConcept C2778794669 @default.
- W2381993477 hasConcept C28005876 @default.
- W2381993477 hasConcept C55493867 @default.
- W2381993477 hasConcept C61174792 @default.
- W2381993477 hasConcept C86803240 @default.
- W2381993477 hasConceptScore W2381993477C117277713 @default.
- W2381993477 hasConceptScore W2381993477C127445978 @default.
- W2381993477 hasConceptScore W2381993477C160268369 @default.
- W2381993477 hasConceptScore W2381993477C169760540 @default.
- W2381993477 hasConceptScore W2381993477C170493617 @default.
- W2381993477 hasConceptScore W2381993477C185592680 @default.
- W2381993477 hasConceptScore W2381993477C197341189 @default.
- W2381993477 hasConceptScore W2381993477C2778794669 @default.
- W2381993477 hasConceptScore W2381993477C28005876 @default.
- W2381993477 hasConceptScore W2381993477C55493867 @default.
- W2381993477 hasConceptScore W2381993477C61174792 @default.
- W2381993477 hasConceptScore W2381993477C86803240 @default.
- W2381993477 hasOpenAccess W2381993477 @default.
- W2381993477 hasRelatedWork W1729538686 @default.
- W2381993477 hasRelatedWork W1964731885 @default.
- W2381993477 hasRelatedWork W1983556061 @default.
- W2381993477 hasRelatedWork W2002052527 @default.
- W2381993477 hasRelatedWork W2016295704 @default.
- W2381993477 hasRelatedWork W2041185628 @default.
- W2381993477 hasRelatedWork W2066054859 @default.
- W2381993477 hasRelatedWork W2080669600 @default.
- W2381993477 hasRelatedWork W2089295602 @default.
- W2381993477 hasRelatedWork W2091558650 @default.
- W2381993477 hasRelatedWork W2117341653 @default.
- W2381993477 hasRelatedWork W2127394252 @default.
- W2381993477 hasRelatedWork W2163975887 @default.
- W2381993477 hasRelatedWork W2373966101 @default.
- W2381993477 hasRelatedWork W2461993442 @default.
- W2381993477 hasRelatedWork W2546978976 @default.
- W2381993477 hasRelatedWork W2599115106 @default.
- W2381993477 hasRelatedWork W3194473385 @default.
- W2381993477 hasRelatedWork W2522080066 @default.
- W2381993477 hasRelatedWork W2995636397 @default.
- W2381993477 isParatext "false" @default.
- W2381993477 isRetracted "false" @default.
- W2381993477 magId "2381993477" @default.
- W2381993477 workType "article" @default.