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- W2381995876 abstract "Objective To discuss the neuroprotective effect of buflomedil hydrochloride after focal cerebral ischemia in rats and its mechanism. Methods Thirty healthy male SD rats were randomly divided into sham-operation, pure ischemia, buflomedil hydrochloride 5 mg/kg, 10 mg/kg and 20 mg/kg treated groups (n=6 in each group). The model of middle cerebral artery (MCA) occlusion was prepared using the intraluminal thread method. The neurological deficit score was evaluated; the levels of endothelin and calcitonin gene-related peptide (CGRP) in brain tissues were measured after 24 hours. Results Neurological deficit scores in the buflomedil hydrochloride 5, 10 and 20 mg/kg groups were 1.83±0.41, 1.67±0.82 and 1.50±0.55, respectively. As compared with 3.0±0.63 in the pure ischemia group, there were significant differences (P0.05, P0.01 and P0.01); the levels of their endothelin were 169 ±39 , 155±42 and 144±27 pg/ml, respectively. As compared with 217±51 pg/ml in the pure ischemia group, there were significant differences (P0.05, P0.01 and P0.01); and the levels of their CGRP were 150±44, 170±44 and 173±54 pg/ml, respectively. As compared with 96±40 pg/ml in the pure ischemia group, there were significant differences (P0.05, P0.01 and P0.01). It showed that there was a dose-effect relationship between them. Conclusion Buflomedil hydrochloride may have neuroprotective effect on neurological injury caused by focal cerebral ischemia, and its mechanism may be associated with the reducing of abnormally increased endothelin and the increased levels of CGRP in brain tissues after cerebral ischemia." @default.
- W2381995876 created "2016-06-24" @default.
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- W2381995876 date "2006-01-01" @default.
- W2381995876 modified "2023-09-26" @default.
- W2381995876 title "Effect of buflomedil hydrochloride on endothelin and calcitonin gene-related peptide levels in focal cerebral ischemia in rats" @default.
- W2381995876 hasPublicationYear "2006" @default.
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