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- W2381999295 abstract "Objective To study osteoporosis generating in the offspring of homozygous (~ -/-) OPG knockout mice. Methods OPG~ -/-knockout mice were used to mate. Conditions of parental generation propagating and offspring developing were observed.Gene phenotype was identified with PCR.Total bone mineral density(BMD) were determined using dual energey X-ray absorprion(DEXA), femur mechanical properties were evaluated using a three-point test, the sclerous tissues slices of lumbar vertebral body stained with picric acid-fuchsin were used to assess bone tissue morphometry static anylysis,the gene expression of BMP-2、Runx2 in the L_1 vertebral body were assayed by Real time RT PCR in 10 16-week-old offspring of OPG~ -/-mice and 10 16-week-old wild type(+/+) offspring of heterozygous(-/+)OPG knockout mice. Results OPG~ -/-mice were viable and fertial,the offspring could grow and develop normally and revealed the same OPG deletion with parental generation. Compared with OPG~ +/+ mice, in OPG~ -/-mice, Total BMD, femur maximum load,stiffness, lumbar vertebral body Tb.N,Tb.Th decreased obviously(t=5.740,6.069,6.859,6.891, 3.558, P0.01); femur break load, lumbar vertebral body Tb.Ar% decreased(t=3.157, 3.329,P0.05); femur maximum elong,break elong obviously increased(t=-3.868,-3.276,P0.01);lumbar vertebral body Tb.Sp increased(t=-2.575, P0.05);lumbar vertebral body gene expression of Runx2 increased(t=-3.738,P0.05); lumbar vertebral body gene expression of BMP-2 increased,but the difference had not statistical significance(t=-1.589,P0.05). Conclusions OPG~ -/-mice appears severe osteoporosis,and it can serve as an excellent osteoporosis animal model." @default.
- W2381999295 created "2016-06-24" @default.
- W2381999295 creator A5025684476 @default.
- W2381999295 date "2008-01-01" @default.
- W2381999295 modified "2023-09-23" @default.
- W2381999295 title "Study on osteoporosis in offspring of OPG knockout mice" @default.
- W2381999295 hasPublicationYear "2008" @default.
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