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- W2381999722 abstract "Objective To investigate the effect of Batroxobin on activation of C-Jun NH2-terminal kinase (JNK) and extracelluar-regulated protein kinases (ERK) after focal cerebral ischemia reperfusion (IR) injury in rats. Methods The rats subjected to middle cerebral artery occlusion with intranall filament occlusion were injected intraperitoneally with Batroxobin before reperfusion. Neuroprotective effect of Batroxobin on IR was evaluated in terms of TTC staining,morphology,and TUNEL assay. In addition,immunohistochemistry and immunoblotting were used to detect JNK and ERK expression. Results Compared with the sham group,the cerebral infarct volume ratio, necrosis, and apoptotic cell death were more evident in IR-treated rats at 22h. Batroxobin significantly decreased all of the above parameters compared with the IR group. At a molecular basis,IR significantly increased JNK and ERK immunoreactivity and expression. Batroxobin decreased JNK but increased ERK expression at 6h after reperfusion. Conclusions These findings suggest that Batroxobin treatment have neuroprotective effect against IR injury in rats,and that this may be associated with differentialy regulation of ERK and JNK expression." @default.
- W2381999722 created "2016-06-24" @default.
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- W2381999722 date "2006-01-01" @default.
- W2381999722 modified "2023-09-24" @default.
- W2381999722 title "Effects of batroxobin on the activation of JNK and ERK after focal cerebral ischemia-reperf usion injury in rats" @default.
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