Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382000329> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2382000329 abstract "OBJECTIVE:To investigate the proliferation and cell apoptosis effects of combination treatment with L-carnitine and EPI on lung adenocarcinoma GLC-82 cell.METHODS: The cell proliferation was examined by MTT assay.Cell cycle and cell apoptosis were analyzed by flow cytometry.The expression of Bcl-2,Bcl-xl and Bax proteins were measured by Western blot.RESULTS: After 24 h and 48 h,the proliferation rate of L-carnitine(20 μg/mL) were 37.56%(F=46.287,P=0.001) and 33.33%(F=41.638,P=0.001),respectively.Cells were treated with L-carnitine and EPI,which reduced the inhibitory effects on GLC-82 cell.After 24 h and 48 h,the antagonized rate of combination treatment were 12.14%(F=20.527,P=0.002) and 18.52%(F=27.269,P=0.001),respectively.The difference was significant.The expression of Bcl-2 and Bcl-xl proteins was up-regulated by L-carnitine.The expression of Bax protein was no difference.The expression of Bcl-2 and Bcl-xl proteins were significantly increased by combination treatment with L-carnitine and EPI.CONCLUSIONS:Combination treatment with L-carnitine and EPI can weaken the cytotoxicity of EPI on GLC-82 cells.After treated with L-carnitine,the proportion of G_0/G_1 phase is significantly increased,S-phase cells is reduced,the phenomenon of induced early apoptosis is disappeared and cell apoptosis is significantly decreased by upregulating the expression of Bcl-2 and Bcl-xl." @default.
- W2382000329 created "2016-06-24" @default.
- W2382000329 creator A5081717691 @default.
- W2382000329 date "2013-01-01" @default.
- W2382000329 modified "2023-09-22" @default.
- W2382000329 title "Effect of combination treatment with L-carnitine and epirubicin on proliferation and apoptosis in GLC-82 cell and its mechanism" @default.
- W2382000329 hasPublicationYear "2013" @default.
- W2382000329 type Work @default.
- W2382000329 sameAs 2382000329 @default.
- W2382000329 citedByCount "0" @default.
- W2382000329 crossrefType "journal-article" @default.
- W2382000329 hasAuthorship W2382000329A5081717691 @default.
- W2382000329 hasConcept C104317684 @default.
- W2382000329 hasConcept C1491633281 @default.
- W2382000329 hasConcept C153911025 @default.
- W2382000329 hasConcept C185592680 @default.
- W2382000329 hasConcept C190283241 @default.
- W2382000329 hasConcept C2776415932 @default.
- W2382000329 hasConcept C2778435403 @default.
- W2382000329 hasConcept C2780783641 @default.
- W2382000329 hasConcept C29537977 @default.
- W2382000329 hasConcept C502942594 @default.
- W2382000329 hasConcept C553184892 @default.
- W2382000329 hasConcept C55493867 @default.
- W2382000329 hasConcept C62112901 @default.
- W2382000329 hasConcept C86803240 @default.
- W2382000329 hasConceptScore W2382000329C104317684 @default.
- W2382000329 hasConceptScore W2382000329C1491633281 @default.
- W2382000329 hasConceptScore W2382000329C153911025 @default.
- W2382000329 hasConceptScore W2382000329C185592680 @default.
- W2382000329 hasConceptScore W2382000329C190283241 @default.
- W2382000329 hasConceptScore W2382000329C2776415932 @default.
- W2382000329 hasConceptScore W2382000329C2778435403 @default.
- W2382000329 hasConceptScore W2382000329C2780783641 @default.
- W2382000329 hasConceptScore W2382000329C29537977 @default.
- W2382000329 hasConceptScore W2382000329C502942594 @default.
- W2382000329 hasConceptScore W2382000329C553184892 @default.
- W2382000329 hasConceptScore W2382000329C55493867 @default.
- W2382000329 hasConceptScore W2382000329C62112901 @default.
- W2382000329 hasConceptScore W2382000329C86803240 @default.
- W2382000329 hasLocation W23820003291 @default.
- W2382000329 hasOpenAccess W2382000329 @default.
- W2382000329 hasPrimaryLocation W23820003291 @default.
- W2382000329 hasRelatedWork W1999867736 @default.
- W2382000329 hasRelatedWork W2124932143 @default.
- W2382000329 hasRelatedWork W2353578013 @default.
- W2382000329 hasRelatedWork W2363984220 @default.
- W2382000329 hasRelatedWork W2364692508 @default.
- W2382000329 hasRelatedWork W2368179753 @default.
- W2382000329 hasRelatedWork W2381349774 @default.
- W2382000329 hasRelatedWork W2383613191 @default.
- W2382000329 hasRelatedWork W2383758174 @default.
- W2382000329 hasRelatedWork W2384514607 @default.
- W2382000329 hasRelatedWork W2385248283 @default.
- W2382000329 hasRelatedWork W2390335759 @default.
- W2382000329 hasRelatedWork W2392224847 @default.
- W2382000329 hasRelatedWork W2392973459 @default.
- W2382000329 hasRelatedWork W2394364159 @default.
- W2382000329 hasRelatedWork W3009359865 @default.
- W2382000329 hasRelatedWork W3031739751 @default.
- W2382000329 hasRelatedWork W3031903102 @default.
- W2382000329 hasRelatedWork W3032637375 @default.
- W2382000329 hasRelatedWork W3092602616 @default.
- W2382000329 isParatext "false" @default.
- W2382000329 isRetracted "false" @default.
- W2382000329 magId "2382000329" @default.
- W2382000329 workType "article" @default.