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- W2382001569 abstract "Objective To study the stimulating effect of activin A on fibroblasts of rat kindney.Methods Fibroblasts separated from SD rat kindney were cultured in diferent medium contained activin A or activin A and follistatin(FS) or FS in different concentration.The proliferation of renal fibroblasts was assayed by MTT method.The α-SMA mRNA expression in cultured renal fibroblasts was examined by RT-PCR.The α-SMA protein expression in culutred renal fibroblasts was observed with immunocytochemistry.Results The rat renal fibroblasts stimulated with activin A had significant higher OD value and higher expression of α-SMAmRNA and protein than that of control group and group stimulated with FS.Conclusion The activin A could stimulate fibroblasts proliferating and activating,and might play an important role in the mechanism of renal fibrosis." @default.
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- W2382001569 date "2006-01-01" @default.
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- W2382001569 title "Stimuluss of activin A to proliferation and activation of rat renal fibroblasts in culture" @default.
- W2382001569 hasPublicationYear "2006" @default.
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