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- W2382015087 abstract "Objective To study the effects of ara saponins of Panax notoginseng leaves(APnL)on inhibiting naloxone-precipitated morphine withdrawal symptoms in morphine dependent rats,rats and on intracellular calciumions in hippocampus of morphine withdrawal rats.Methods The models of morphine physical dependent rats and withdrawal syndrome were developed by subcutaneous injection of morphine in gradually increasing doses and intraperitoneal injection of naloxone,respectively.The rats were treated with APnL given intragastrically in various doses at the same time when they developed naloxone-precipitated morphine withdrawal symptoms.On day 6,50 mg/kg morphine was injected at 8:00.Withdrawal syndrome was precipitated by intraperitoneal injection of naloxone(5 mg/kg).The withdrawal syndrome and body weight loss were observed.After 1 hour,the hippocampal neurons were prepared from acutely isolated hippocampus The contents of [Ca2+]i of different groups were measured by flow cytometry.Results ①Naloxone was intraperitoneally injected,5 days after chronic treatment with escalating doses of morphine.The body weight loss and number of jumping of morphine withdrawn rats were increased compared with morphine group(P0.01).②Three doses of ApnL decreased the body weight loss and number of jumping.③APnL downregulated contents of [Ca2+]i in hippocampus in naloxone-precipitated withdrawal rats.200 mg/kg was the best dose.Conclusion APnL significantly relieve the naloxone-precipitated withdrawal syndrome in morphine dependent rats and inhibit contents of [Ca2+]i in hippocampus of naloxone-precipitated withdrawal rats." @default.
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- W2382015087 modified "2023-09-23" @default.
- W2382015087 title "Effects of arasaponins Panax notoginseng leaves on inhibiting withdrawal symptoms in morphine dependent rats and on intracellular calciumions in their hippocampal neurons" @default.
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