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- W2382016593 abstract "AIM:To compare the efficiency of prednisone and 6% hydroxyethylstarch in the prevention of moderate and severe ovarian hyperstimulation syndrome(OHSS). METHODS: A total of 207 OHSS high-risk patients and 207 cycles of in vitro fertilization and embryo transfer(IVF-ET) programme with estradiol serum concentration≥4000 pg/mL on the day of hCG injection and/or≥15 oocyte collection were prospective and randomized divided into A,B and C three groups.The patients in group A(66 cycles) orally took prednisone 5 mg tid on the day of hCG injection for 2 d,and then changed to 5 mg qd for 5 d;the patients in group B(75 cycles) were infused with 500 mL 6% hydroxyethylstarch on the day of oocyte collection for 3d;the patients in group C(66 cycles) were treated with prednisone and hydroxyethylstarch.The incidence of moderate and severe OHSS and the other corresponding indexes among the three groups were analyzed.RESULTS:There have 60 cycles were transferred in group A,clinical pregnancy rate was 50% and the incidence of moderate and severe OHSS was 3.03%;65 cycles were transferred in group B,clinical pregnancy rate was 44.6%,and the incidence of moderate and severe OHSS was 13.33%;59 cycles were transferred in group C,clinical pregnancy rate was 42.4% and the incidence of moderate and severe OHSS was 3.03%.There was no significant difference in pregnancy outcome among the three groups(P0.05),but the incidence of moderate and severe OHSS in group B was higher than those in group A and group C(P0.05).CONCLUSION: Oral administration of prednisone have no effect on pregnant rate of IVF and it is a cheaper,more convenient and effective alternative to 6% hydroxyethylstarch in moderate and severe OHSS prevention." @default.
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- W2382016593 date "2011-01-01" @default.
- W2382016593 modified "2023-09-24" @default.
- W2382016593 title "Comparison of prednisone versus hydroxyethylstarch for prevention of moderate and severe ovarian hyperstimulation syndrome" @default.
- W2382016593 hasPublicationYear "2011" @default.
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