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- W2382018834 abstract "Objective:To investigate the linkage relationship between the gene of familial focal segmental glomerulosclerosis(FFSGS) and it autosomal recessive chromosome in a family.Methods:A three-generation Chinese family was investigated.The total number of members was 27 in this family and given systemic physical examinations.Venous blood samples were taken for genetic analysis.DNA was extracted from peripheral blood using phenol-chloroform method.Ten microsatellite markers spanning the interest regions on chromosome 1q25-31 were elected.These markers included D1S452,D1S242,D1S416,D1S466,D1S240,D1S254,D1S202,D1S222,D1S238 and D1S413.The DNA from each sample was amplified for the 10 markers.After polymerase chain reaction(PCR),PCR products of chromosome 1 with markers were subjected to electrophoresis.Then the length of the PCR products was judged at ABI PRISMTM 310 Genetic Analyzer.The data of PCR products were analyzed using the software Genescan version 3.1and Genetyper version 3.7(Applied Biosystem,CA,USA).After mendelian checking,the eligible genotyping data were used for linkage analysis.Two-point linkage analysis was performed using the MLINK program version 5.1.Two-piont lod scores calculations were performed. Results:The two-point lod scores were below zero and the maximum lod scores at combination rate(θ)=0.0 were less than-2 for all the markers. Thus,the linkage result showed no evidence that the disease locus was linked to any of these selected markers. Conclusion:There was no evidence that the Chinese family was linked to 1q25-31" @default.
- W2382018834 created "2016-06-24" @default.
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- W2382018834 date "2007-01-01" @default.
- W2382018834 modified "2023-09-23" @default.
- W2382018834 title "Genetic study of Familial focal segmental glomerulosclerosis(FFSGS)" @default.
- W2382018834 hasPublicationYear "2007" @default.
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