Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382023258> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2382023258 abstract "Objective To study the expression of angiotensin converting enzyme(ACE),angiotensin Ⅱ receptor 1(AT1R),and angiotensin Ⅱ receptor 2(AT2R) in rabbits with hyperthyroid cardiomyopathy induced by levothyroxine(L-Thy).Methods A rabbit model of hyperthyroidism was established by daily intraperitoneal injections of L-Thy(45μg/kg per day,28 d).Forty New Zealand rabbits were randomly divided into fours groups:control group(n=10),L-Thy group(L-Thy only,n=10),imidapril group(L-Thy+ imidapril,n=10),and valsartan group(L-Thy+valsartan,n=10).Ventricular tissues were collected at 4 weeks.Cardiac hypertrophy index and cardiomyocyte diameter were detected.Cardiac fibrosis was displayed by Masson′s stain and collegen volume fraction(CVF)was measured using pathological image analytic system.Plasm and cardiac angiotensin Ⅱ concentration were measured with radioimmunoassays(RIAs).mRNA expression of ACE,AT1R,and AT2R were semi-quantified with RT-PCR.Expression of ACE,AT1R,and AT2R protein was evaluated with Western blot analysis.Results Compared with control group,rabbits merely treated with L-Thy displayed remarkable myocardial hypertrophy and extracellular matrix fibrosis.Increased plasm and tissue AngⅡ was detected in L-Thy group.RT-PCR and Western blot analysis revealed enhanced mRNA and protein expression of ACE,AT1R,and AT2R.Our study demonstrated that both imidapril and valsartan alleviated cardiomyocyte hypertrophy and extracellular matrix fibrosis induced by L-Thy.Compared with L-Thy and valsartan group,imidapril group showed significantly lower plasm /tissue AngⅡ concentration and more effective inhibition of extracellular matrix fibrosis.Imidapril did not alter expression of ACE,AT1R,and AT2R.Plasm concentration of AngⅡ was markedly higher in valsartan group compared with L-Thy group,whereas tissue AngⅡ concentration was not significantly different between the two groups.In valsartan group,AT1R and AT2R mRNA expressions were significantly upregulated,whereas valsartan did not change expression of ACE.Conclusion Expression of ACE,AT1R,and AT2R is upregulated in rabbits with hyperthyroid cardiomyopathy induced by L-Thy.Renin-angiotension system(RAS)may play important role in hyperthyroid cardiomyopathy.Imidapril and valsartan may exert benefical effects on hyperthyroid cardiomyopathy via improring myocardial remodeling." @default.
- W2382023258 created "2016-06-24" @default.
- W2382023258 creator A5079407464 @default.
- W2382023258 date "2010-01-01" @default.
- W2382023258 modified "2023-09-26" @default.
- W2382023258 title "Expression of angiotensin converting enzyme,angiotensin II receptor 1,and angiotensin II receptor 2 in rabbits with hyperthyroid cardiomyopathy" @default.
- W2382023258 hasPublicationYear "2010" @default.
- W2382023258 type Work @default.
- W2382023258 sameAs 2382023258 @default.
- W2382023258 citedByCount "0" @default.
- W2382023258 crossrefType "journal-article" @default.
- W2382023258 hasAuthorship W2382023258A5079407464 @default.
- W2382023258 hasConcept C104317684 @default.
- W2382023258 hasConcept C104849204 @default.
- W2382023258 hasConcept C123915805 @default.
- W2382023258 hasConcept C126322002 @default.
- W2382023258 hasConcept C134018914 @default.
- W2382023258 hasConcept C170493617 @default.
- W2382023258 hasConcept C185592680 @default.
- W2382023258 hasConcept C198710026 @default.
- W2382023258 hasConcept C27016395 @default.
- W2382023258 hasConcept C2776415932 @default.
- W2382023258 hasConcept C2777387769 @default.
- W2382023258 hasConcept C2777420927 @default.
- W2382023258 hasConcept C2780559512 @default.
- W2382023258 hasConcept C2908929049 @default.
- W2382023258 hasConcept C3018763269 @default.
- W2382023258 hasConcept C55493867 @default.
- W2382023258 hasConcept C71924100 @default.
- W2382023258 hasConcept C84393581 @default.
- W2382023258 hasConceptScore W2382023258C104317684 @default.
- W2382023258 hasConceptScore W2382023258C104849204 @default.
- W2382023258 hasConceptScore W2382023258C123915805 @default.
- W2382023258 hasConceptScore W2382023258C126322002 @default.
- W2382023258 hasConceptScore W2382023258C134018914 @default.
- W2382023258 hasConceptScore W2382023258C170493617 @default.
- W2382023258 hasConceptScore W2382023258C185592680 @default.
- W2382023258 hasConceptScore W2382023258C198710026 @default.
- W2382023258 hasConceptScore W2382023258C27016395 @default.
- W2382023258 hasConceptScore W2382023258C2776415932 @default.
- W2382023258 hasConceptScore W2382023258C2777387769 @default.
- W2382023258 hasConceptScore W2382023258C2777420927 @default.
- W2382023258 hasConceptScore W2382023258C2780559512 @default.
- W2382023258 hasConceptScore W2382023258C2908929049 @default.
- W2382023258 hasConceptScore W2382023258C3018763269 @default.
- W2382023258 hasConceptScore W2382023258C55493867 @default.
- W2382023258 hasConceptScore W2382023258C71924100 @default.
- W2382023258 hasConceptScore W2382023258C84393581 @default.
- W2382023258 hasLocation W23820232581 @default.
- W2382023258 hasOpenAccess W2382023258 @default.
- W2382023258 hasPrimaryLocation W23820232581 @default.
- W2382023258 hasRelatedWork W1934016197 @default.
- W2382023258 hasRelatedWork W2031676592 @default.
- W2382023258 hasRelatedWork W2138125275 @default.
- W2382023258 hasRelatedWork W2327780757 @default.
- W2382023258 hasRelatedWork W2358488649 @default.
- W2382023258 hasRelatedWork W2359102141 @default.
- W2382023258 hasRelatedWork W2362312918 @default.
- W2382023258 hasRelatedWork W2370322643 @default.
- W2382023258 hasRelatedWork W2372243833 @default.
- W2382023258 hasRelatedWork W2373512833 @default.
- W2382023258 hasRelatedWork W2374925913 @default.
- W2382023258 hasRelatedWork W2376378023 @default.
- W2382023258 hasRelatedWork W2377706939 @default.
- W2382023258 hasRelatedWork W2385750370 @default.
- W2382023258 hasRelatedWork W2386343257 @default.
- W2382023258 hasRelatedWork W2388807062 @default.
- W2382023258 hasRelatedWork W2391732171 @default.
- W2382023258 hasRelatedWork W2910924166 @default.
- W2382023258 hasRelatedWork W3141714340 @default.
- W2382023258 hasRelatedWork W3143083786 @default.
- W2382023258 isParatext "false" @default.
- W2382023258 isRetracted "false" @default.
- W2382023258 magId "2382023258" @default.
- W2382023258 workType "article" @default.